Estrogen compositions for vaginal administration
First Claim
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1. A pharmaceutical gel composition containing estrogen for vaginal administration comprising:
- (a) at least one estrogen in an amount of about 0.00028% to about 1% by weight of the composition;
(b) at least one gelation polymer; and
(c) at least one aqueous solvent;
wherein a portion of the estrogen in the composition is in suspension at 15°
C.
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Abstract
Pharmaceutical gel compositions containing estrogen for vaginal administration, as well as a method of making the same, are disclosed.
67 Citations
18 Claims
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1. A pharmaceutical gel composition containing estrogen for vaginal administration comprising:
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(a) at least one estrogen in an amount of about 0.00028% to about 1% by weight of the composition;
(b) at least one gelation polymer; and
(c) at least one aqueous solvent;
wherein a portion of the estrogen in the composition is in suspension at 15°
C. - View Dependent Claims (2, 3, 4, 5, 6, 10, 11, 12, 13, 14, 18)
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- 7. The pharmaceutical gel composition of claim I, wherein at least 50% of the estrogen in the composition is in suspension at 15°
- 15. A method of making a pharmaceutical gel composition for vaginal application comprising the step of admixing at least one estrogen in an amount of about 0.00028% to about 1% by weight of the composition with at least one aqueous solvent and at least one gelation polymer to form the pharmaceutical gel composition, wherein a portion of the estrogen in the composition is in suspension at 15°
Specification