System and method for non-invasive glucose monitoring

• US 20070004975A1
• Filed: 06/30/2005
• Published: 01/04/2007
• Est. Priority Date: 06/30/2005
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Zribi, Anis, Chen, Rui, Shih, Min-Yi, Codella, Peter, Gangadharan, Ganesh
• Granted Patent: US 7,627,357 B2
• Time in Patent Office: Days
• US Class Current: 600/318
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: G01J 3/44 Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
• CPC Class Codes: G01J 3/447 Polarisation spectrometry
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/65 Raman scattering

Abstract

A method for determining analyte concentration levels is provided. The method includes acquiring radiation scattered off or transmitted by a target, analyzing at least a first portion of the radiation via a first technique to generate a first measurement of analyte concentration levels, and analyzing at least a second portion of the radiation via a second technique to generate a second measurement of analyte concentration levels. The method further determines analyte concentration levels based on at least one of the first measurement or the second measurement. In addition, a system for implementing the method and a probe for measuring and monitoring the analyte concentration levels is provided.

Claims

1. A method for determining analyte concentration levels, comprising:

acquiring radiation scattered off or transmitted by a target;

analyzing at least a first portion of the radiation via a first technique to generate a first measurement of analyte concentration levels;

analyzing at least a second portion of the radiation via a second technique to generate a second measurement of analyte concentration levels; and

determining analyte concentration levels based on at least one of the first measurement or the second measurement.

2. The method as recited in claim 1, wherein the first technique is a spectroscopic technique and the second technique is a polarimetric technique.

3. The method as recited in claim 1, wherein the first measurement of the analyte concentration levels is generated based on intensity of a shifted wavelength of a beam of photons.

4. The method as recited in claim 3, wherein the second portion of the scattered radiation comprises a portion of the beam of photons having a shift in polarization.

5. The method as recited in claim 4, wherein generating the second measurement of the analyte concentration levels comprises generating the second measurement of the analyte concentration levels based on the shift in polarization.

6. The method as recited in claim 1, wherein analyzing at least the first portion of the scattered radiation via the first technique comprises analyzing at least the first portion of the scattered radiation via Raman spectroscopy.

7. The method as recited in claim 1, comprising determining if errors in the analyte concentration levels are below predetermined estimates.

8. The method as recited in claim 1, wherein determining analyte concentration measurements comprises determining an albumin content based on at least one of the first measurement or the second measurement.

9. The method as recited in claim 1, wherein determining analyte concentration measurements comprises determining an ascorbate content based on at least one of the first measurement or the second measurement.

10. The method as recited in claim 1, wherein determining analyte concentration measurements comprises determining a glucose content based on at least one of the first measurement or the second measurement.

11. A method for determining a glucose concentration, comprising:

filtering radiation scattered or transmitted by an eye such that the radiation is separated into a first component and a second component;

generating a first value of a glucose concentration based upon the first component; and

generating a second value of the glucose concentration based upon the second component and the first value.

12. The method of claim 11, wherein generating the first value of the glucose concentration comprises analyzing the first component using a spectroscopic technique.

13. The method of claim 12, wherein the spectroscopic technique is a Raman spectroscopic technique.

14. The method of claim 11, wherein generating the second value of the glucose concentration comprises analyzing the second component using a polarimetric technique.

15. The method of claim 11, wherein the first component is shifted by wavelength and the second component is shifted by polarization.

16. A system for measuring an analyte concentration, comprising;

a filter configured to separate scattered or transmitted radiation into a first portion and a second portion;

a spectrometer configured to process the first portion to generate a first measurement of analyte concentration levels;

a polarimeter configured to process the second portion to generate a second measurement of analyte concentration levels; and

an analysis component configured to generate analyte concentration levels based upon the first measurement and the second measurement.

17. The system as recited in claim 16, wherein the filter comprises a Rayleigh filter.

18. The system as recited in claim 16, comprising a laser generator configured to generate the scattered or transmitted radiation.

19. The system as recited in claim 16, wherein the analysis component comprises a wearable processor-based device.

20. The system as recited in claim 16, wherein the analyte concentration level comprises glucose concentration.

21. The system as recited in claim 16, wherein the spectrometer comprises a Raman spectrometer.

22. A probe, comprising:

a wearable filter configured to separate scattered or transmitted radiation into a first portion and a second portion;

a wearable spectrometer configured to process the first portion; and

a wearable polarimeter configured to process the second portion.

23. A tangible medium, comprising:

a routine adapted to generate a measurement of analyte concentration levels based upon a spectroscopic measurement of analytes and a polarimetric measurement of the analyte concentration levels.