Device for transdermal sampling
First Claim
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1. A device for transdermal agent sampling comprising:
- (a) a base having a lower side and an upper side;
(b) a plurality of puncturing elements extending from the lower side of the base;
(c) a plurality of holes extending from the lower side of the base to the upper side of the base; and
(d) one or more protrusions extending from the lower side of the base, the protrusions of sufficient height to allow fluid to flow under the base while still permitting the puncturing members to penetrate through the stratum comeum of a subject.
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Abstract
Transdermal agent sampling devices are described which combine arrays of puncturing elements, do not require the use of pumps, and in which the sensing means for detecting the agent is directly proximal to, or comprised within, the array of puncturing elements. An array design that improves the flow of fluid from the skin to the sensor, allowing efficient utilization of the extracted fluid is also described. Devices that are suitable for use in a patch for agent monitoring, in that they are smaller and cheaper to manufacture, as well as being lighter, less obtrusive, and less irritating to the user are also described.
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Citations
18 Claims
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1. A device for transdermal agent sampling comprising:
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(a) a base having a lower side and an upper side;
(b) a plurality of puncturing elements extending from the lower side of the base;
(c) a plurality of holes extending from the lower side of the base to the upper side of the base; and
(d) one or more protrusions extending from the lower side of the base, the protrusions of sufficient height to allow fluid to flow under the base while still permitting the puncturing members to penetrate through the stratum comeum of a subject. - View Dependent Claims (2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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6. A device for transdermal agent sampling comprising:
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(a) a base having an upper side and a lower side, with a plurality of puncturing elements extending from the lower side of the base;
(b) an absorbent membrane contiguous with the upper side of the base; and
(c) means for increasing interstitial fluid evaporation. - View Dependent Claims (7, 8)
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Specification