Medical devices having superhydrophobic surfaces, superhydrophilic surfaces, or both

• US 20070005024A1
• Filed: 06/10/2005
• Published: 01/04/2007
• Est. Priority Date: 06/10/2005
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Schewe, Scott, Weber, Jan, Berg, Brian
• Application Number:
  US11/150,082
• Publication Number:
  US 20070005024A1
• Time in Patent Office: Days
• US Class Current: 604/265
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61M 2205/0222 Materials for reducing friction
• CPC Class Codes: A61M 2205/0238 the material being a coating or protective layer

Abstract

According to an aspect of the invention, medical devices are provided, which have the following (a) one or more superhydrophobic surface regions, (b) one or more superhydrophilic surface regions having a durometer of at least 40 A, or (c) a combination of one or more superhydrophobic surface regions and one or more superhydrophilic surface regions having a durometer of at least 40 A. Such surfaces are created, for example, to provide reduced resistance to the movement of adjacent materials, including adjacent fluids and solids. Examples of medical device surface regions benefiting from the present invention include, for example, outside and/or inside (luminal) surfaces of the following: vascular catheters, urinary catheters, hydrolyser catheters, guide wires, pullback sheaths, left ventricular assist devices, endoscopes, airway tubes and injection needles, among many other devices.

Claims

1. An medical device comprising a surface region selected from (a) a superhydrophobic surface region and (b) a superhydrophilic surface region having a durometer of at least 40 A.

2. The medical device of claim 1, comprising a superhydrophobic surface region.

3. The medical device of claim 2, comprising two or more superhydrophobic surface regions.

4. The medical device of claim 2, wherein said superhydrophobic surface region has advancing and receding water contact angles of 150°

or greater.

5. The medical device of claim 2, wherein said superhydrophobic surface region has advancing and receding water contact angles of 160°

or greater.

6. The medical device of claim 2, wherein said superhydrophobic surface region corresponds to a tissue contacting surface of said medical device.

7. The medical device of claim 2, wherein said superhydrophobic surface region corresponds to the surface of a fluid conduit within said medical device.

8. The medical device of claim 7, wherein said fluid conduit is a cylindrical lumen with a diameter less than 250 micrometers.

9. The medical device of claim 7, wherein said fluid conduit is an annular space with an annular spacing less than 250 micrometer.

10. The medical device of claim 7, wherein said fluid conduit is a conduit for bodily fluid.

11. The medical device of claim 7, wherein said fluid conduit is a conduit for non-bodily fluids.

12. The medical device of claim 2, wherein said device is an internal medical device.

13. The medical device of claim 2, wherein said device is a balloon catheter.

14. The medical device of claim 13, wherein said superhydrophobic surface region lines an inflation lumen for said balloon.

15. The medical device of claim 14, wherein inflation fluid flowing by said superhydrophobic surface region has a slip length of at least 10 μ

m.

16. The medical device of claim 14, wherein inflation fluid flowing by said superhydrophobic surface region has a slip length of at least 50 μ

m.

17. The medical device of claim 13, wherein said superhydrophobic surface region is configured to contact a medical article.

18. The medical device of claim 17, wherein said medical article is a guidewire and said superhydrophobic surface region lines a guidewire lumen within said balloon catheter.

19. The medical device of claim 2, wherein said medical article is a stent and said superhydrophobic surface region is a balloon surface.

20. The medical device of claim 2, wherein said device is selected from a vascular catheter, a urinary catheter, a hydrolyser catheter, a guide wire, a pullback sheath, a left ventricular assist device, an endoscope, an airway tube and an injection needle.

21. The medical device of claim 2, wherein said superhydrophobic surface region is a textured fluorocarbon material surface.

22. The medical device of claim 2, wherein said superhydrophobic surface region is a textured fluorocarbon polymer surface.

23. The medical device of claim 22, wherein said surface region is textured using a laser ablation technique or a plasma etching technique.

24. The medical device of claim 2, wherein said superhydrophobic surface region corresponds to a coating formed over an underlying substrate.

25. The medical device of claim 24, wherein said coating is a multilayer coating.

26. The medical device of claim 24, wherein said coating comprises a fluorocarbon polymer layer.

27. The medical device of claim 26, wherein said fluorocarbon polymer layer is provided over a textured surface.

28. The medical device of claim 26, wherein said fluorocarbon polymer coating is deposited by a process selected from chemical vapor deposition and glow discharge deposition.

29. The medical device of claim 25, wherein said multilayer coating comprises a particulate layer.

30. The medical device of claim 29, wherein said particulate layer is a carbon nanotube layer.

31. The medical device of claim 25, wherein said multilayer coating comprises multiple layers of alternating charge.

32. The medical device of claim 31, wherein said layers of alternating charge comprise a negatively charged polyelectrolyte-containing layer, a positively charged polyelectrolyte-containing layer, and a charged particle layer.

33. The medical device of claim 31, wherein said multilayer coating comprises a fluorinated polyelectrolyte.

34. The medical device of claim 24, wherein said coating comprises a sol-gel layer.

35. The medical device of claim 34, wherein said coating further comprises an inherently hydrophobic layer over said sol-gel layer.

36. The medical device of claim 1, comprising a superhydrophilic surface region having a durometer of at least 40 A.

37. The medical device of claim 36, comprising two or more superhydrophilic surface regions having a durometer of at least 40 A.

38. The medical device of claim 36, wherein said superhydrophilic surface region has a static water contact angle of 2°

or less.

39. The medical device of claim 36, wherein said superhydrophilic surface region has a static water contact angle of 1°

or less.

40. The medical device of claim 36, wherein said superhydrophilic surface region corresponds to a tissue contacting surface of said medical device.

41. The medical device of claim 36, wherein said superhydrophilic surface region is configured to contact a medical article.

42. The medical device of claim 36, wherein said device is a balloon catheter.

43. The medical device of claim 36, wherein said device is selected from a vascular catheter, a urinary catheter, a hydrolyser catheter, a guide wire, a pullback sheath, an endoscope, an airway tube and an injection needle.

44. The medical device of claim 36, wherein said superhydrophilic surface region corresponds to a superhydrophilic coating over an underlying substrate.

45. The medical device of claim 44, wherein said coating is a multilayer coating.

46. The medical device of claim 45, wherein said coating comprises layers of alternating charge.

47. The medical device of claim 46, wherein said layers of alternating charge comprise a negatively charged polyelectrolyte-containing layer and a positively-charged polyelectrolyte containing layer.

48. The medical device of claim 47, wherein said layers of alternating charge further comprise charged particles.

49. The medical device of claim 36, wherein said device is an internal medical device.