Photonic crystal biosensor structure and fabrication method

• US 20070009380A1
• Filed: 07/08/2005
• Published: 01/11/2007
• Est. Priority Date: 07/08/2005
• Status: Active Grant

• Current Assignee: X-Body Incorporated (Bristol-Myers Squibb Company)
• Original Assignee: Sru Biosystems Incorporated
• Inventors: Cunningham, Brian
• Granted Patent: US 7,521,769 B2
• Time in Patent Office: Days
• US Class Current: 422/58
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: G01N 2021/7776 Index
• CPC Class Codes: G01N 21/00 Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light G01N3/00 - G01N19/00 take precedence
• CPC Class Codes: G01N 21/4788 Diffraction for sizing particles G01N15/0205
• CPC Class Codes: G01N 21/55 Specular reflectivity

Abstract

The invention provides sensor compositions and method of making sensors.

Claims

1. A sensor comprising a nanoporous material, having a low refractive index, supported on a bottom surface by a substrate, and coated on a top surface with a high dielectric constant dielectric coating;

wherein, the high dielectric constant dielectric coating or the high dielectric constant dielectric coating in combination with the nanoporous material form a sub-wavelength period grating structure;

wherein, when the sensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum; and

wherein the depth and period of the sub-wavelength period grating structure are less than the wavelength of the resonant grating effect.

2. The sensor of claim 1, wherein a narrow band of optical wavelengths is reflected from the sensor when the sensor is illuminated with a broad band of optical wavelengths.

3. The sensor of claim 1, wherein the refractive index of the nanoporous material is from about 1.1 to about 2.2.

4. The sensor of claim 1, wherein the refractive index of the nanoporous material is from about 1.1 to about 1.5.

5. The sensor of claim 1, wherein the period of the sub-wavelength period grating structure is about 50 nm to about 1,500 nm and the depth of the sub-wavelength period grating structure is about 50 nm to about 900 nm.

6. The sensor of claim 1, wherein the nanoporous material is porous silica xerogel, porous aerogels, porous hydrogen silsesquioxane, a B staged polymer, porous methyl silsesquioxane, porous poly(arylene ether), or combinations thereof.

7. The sensor of claim 1, wherein the substrate comprises glass, plastic or epoxy.

8. The sensor of claim 1, wherein the refractive index of the dielectric coating is about 1.8 to about 3.0.

9. The sensor or claim 1, wherein the dielectric coating comprises tin oxide, tantalum pentoxide, zinc sulfide, titanium dioxide, silicon nitride, or a combination thereof.

10. The sensor of claim 1, wherein the refractive index of the substrate is about 1.4 to about 1.6.

11. The sensor of claim 1, wherein the thickness of the dielectric coating is about 30 nm to about 700 nm and the thickness of the nanoporous material is about 10 nm to about 5,000 nm.

12. The sensor of claim 1, wherein the dielectric coating has a cover layer on its top surface.

13. The sensor of claim 1, wherein the sensor further comprises one or more specific binding substances immobilized on the high dielectric constant dielectric coating.

14. The sensor of claim 12, wherein the sensor further comprises one or more specific binding substances immobilized on the cover layer.

15. The sensor of claim 13, wherein the one or more specific binding substances do not comprise a detectable label.

16. The sensor of claim 13, wherein the one or more specific binding substance are bound to their binding partners.

17. The sensor of claim 16, wherein the one or more specific binding substances and the binding partners do not comprise a detectable label.

18. The sensor of claim 13, wherein the one or more specific binding substances are arranged in an array on the high dielectric constant dielectric coating.

19. The sensor of claim 14, wherein the one or more specific binding substances are arranged in an array on the cover layer.

20. A sensor comprising a waveguiding structure formed by a waveguiding film covering a substrate, wherein the waveguiding film has a refractive index higher than the refractive index of the substrate, and a diffraction grating is contained with in the waveguiding structure, wherein the diffraction grating is comprised of a nanoporous material having a low dielectric constant.

21. The sensor of claim 20, wherein the refractive index of the nanoporous material is from about 1.1 to about 1.5.

22. The sensor of claim 20, wherein the refractive index of the nanoporous material is from about 1.1 to about 2.2.

23. The sensor of claim 20, wherein the nanoporous material is porous silica xerogel, porous aerogels, porous hydrogen silsesquioxane, a B staged polymer, porous methyl silsesquioxane, porous poly(arylene ether), or combinations thereof.

24. The sensor of claim 20, wherein the substrate comprises glass, epoxy, or plastic.

25. The sensor of claim 20, wherein the waveguiding film comprises tin oxide, tantalum pentoxide, zinc sulfide, titanium dioxide, silicon nitride, or a combination thereof.

26. The sensor of claim 20, wherein the waveguiding film comprises a polymer.

27. The sensor of claim 20, wherein the sensor further comprises one or more specific binding substances immobilized on the waveguiding film.

28. The sensor of claim 27, wherein the one or more specific binding substances do not comprise a detectable label.

29. The sensor of claim 28, wherein the one or more specific binding substance are bound to their binding partners.

30. The sensor of claim 29, wherein the one or more specific binding substances and the binding partners do not comprise a detectable label.

31. The sensor of claim 27, wherein the one or more specific binding substances are arranged in an array on the high refractive index dielectric coating.