Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
First Claim
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1. An isolated human umbilicus-derived cell capable of self-renewal and expansion in culture and having the potential to differentiate into cells of other phenotypes, wherein the cell does not substantially stimulate naï
- ve CD4+ T cells, and expresses PD-L2, but not HLA-G, CD 178, HLA-DR, HLA-DP, HLA-DQ, CD80, CD86, or B7-H2.
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Abstract
Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
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Citations
15 Claims
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1. An isolated human umbilicus-derived cell capable of self-renewal and expansion in culture and having the potential to differentiate into cells of other phenotypes, wherein the cell does not substantially stimulate naï
- ve CD4+ T cells, and expresses PD-L2, but not HLA-G, CD 178, HLA-DR, HLA-DP, HLA-DQ, CD80, CD86, or B7-H2.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
Specification