Method and device for coating a continuous strip of microprojection members

• US 20070009587A1
• Filed: 06/20/2006
• Published: 01/11/2007
• Est. Priority Date: 06/21/2005
• Status: Abandoned Application

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Daddona, Peter, Dohner, John
• Application Number:
  US11/472,165
• Publication Number:
  US 20070009587A1
• Time in Patent Office: Days
• US Class Current: 424/448
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61M 2037/0053 Methods for producing microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

The present invention provides a device and method for selectively providing multiple applications of an agent formulation on the skin piercing portions of a microprojection member to form an agent-containing coating on the microprojections. The formulation is dried to form a solid coating which contains the agent. A continuous conveyor strip bearing multiple microprojection members is spiral wrapped around a product drum so that each microprojection member is conveyed past a reservoir a plurality of times. The reservoir is configured to transfer an application of agent formulation onto the microprojection member each time it passes the reservoir.

Claims

1. A device for applying a biologically active agent formulation to a microprojection member having a plurality of stratum corneum-piercing microprojections, comprising a flexible conveyor strip having said microprojection member mounted thereon, a product drum, wherein said conveyor strip is spiral wrapped around said product drum, and a reservoir of said biologically active agent formulation adapted to cooperate with said product drum to transfer at least one application of said biologically active agent onto said microprojections as said conveyor strip travels around said product drum.

2. The device of claim 1, wherein at least two applications of said biologically active agent are transferred to said microprojections.

3. The device of claim 1, wherein said product drum rotates with said flexible conveyor strip.

4. The device of claim 1, wherein said product drum is fixed.

5. The device of claim 4, wherein said product drum further includes a spiral flight configured to constrain said conveyor strip in a spiral wrap pattern.

6. The device of claim 5, wherein said product drum further includes a plurality of air holes on a surface of said product drum between said spiral flight, wherein said air holes are configured to transmit compressed air to reduce friction between said conveyor strip and said product drum.

7. The device of claim 1, wherein said reservoir comprises an agent formulation holding surface and wherein said product drum is positioned relative to said holding surface so that said microprojection member is conveyed with said microprojections being immersed at a predetermined level through said agent formulation on said holding surface.

8. The device of claim 6, wherein said agent formulation holding surface comprises an outer surface of a rotatable cylindrically-shaped coating drum adapted to receive a film of said biologically active agent formulation.

9. The device of claim 7, wherein said coating drum is partially immersed in a container of said biologically active agent formulation.

10. The device of claim 8, wherein said coating drum has a surface area sufficient to interact with each wrap of said conveyor strip at a desired location on said product drum.

11. A system for applying a biologically active agent formulation to a microprojection member having a plurality of stratum corneum-piercing microprojections comprising:

a flexible conveyor strip having said microprojection member mounted thereon;

a product drum, wherein said conveyor strip is spiral wrapped around said product drum; and

a reservoir of said biologically active agent formulation adapted to cooperate with said product drum to transfer at least one application of said biologically active agent onto said microprojections as said conveyor strip travels around said product drum;

wherein said conveyor strip has a plurality of said microprojection members mounted thereon.

12. The system of claim 11, wherein at least two applications of said biologically active agent are transferred to said microprojections.

13. The system of claim 11, further including a drying chamber adapted to receive said conveyor strip carrying said microprojection members after transfer of said biologically active agent formulation to said microprojections.

14. The system of claim 11, further including a source of adhesive backing for laminating to said microprojection members.

15. The system of claim 11, further including a cutter to cut individual microprojection members from said conveyor strip.

16. The system of claim 15, further including a plunger for mounting said individual microprojection members on a retainer ring.

17. A method for applying a biologically active agent formulation to a microprojection member having a plurality of stratum corneum-piercing microprojections, comprising the steps of:

providing a flexible conveyor strip having said microprojection member mounted thereon;

spiral wrapping said conveyor strip around a product drum; and

conveying said microprojection member past a reservoir of said biologically active agent formulation to transfer at least one application of said biologically active agent onto said microprojections as said conveyor strip travels around said product drum.

18. The method of claim 17, wherein at least two applications of said biologically active agent are transferred to said microprojections.

19. The method of claim 17, wherein said product drum further includes a spiral flight configured to constrain said conveyor strip in a spiral wrap pattern.

20. The method of claim 19, wherein said product drum further includes a plurality of air holes on a surface of said product drum between said spiral flight, further comprising the step of delivering compressed air through said air holes to reduce friction between said conveyor strip and said product drum.

21. The method of claim 17, wherein said reservoir further comprises a biologically active agent formulation holding surface positioned relative to said product drum so that said microprojection member is conveyed past said reservoir with said microprojections being immersed at a predetermined level through said agent formulation on said holding surface.

22. The method of claim 21, wherein said biologically active agent formulation holding surface comprises a cylindrically-shaped coating drum, further comprising the steps of applying a film of said biologically active agent formulation to said holding surface and rotating said coating drum.

23. The method of claim 22, wherein said step of applying a film of said biologically active agent formulation to said holding surface comprises rotating said coating drum while said coating drum is partially immersed in a container of said biologically active agent formulation.

24. The method of claim 17, further including the step of applying a coating of biologically active agent to multiple microprojection members by providing said conveyor strip with a plurality of said microprojection members mounted thereon.

25. A system for applying a biologically active agent formulation to a microprojection member having a plurality of stratum corneum-piercing microprojections comprising:

a flexible conveyor strip having an adhesive layer and a substantially continuous protective layer removably disposed thereon, said microprojection member being attached to said adhesive layer between said protective layer and said adhesive layer;

a product drum, wherein said conveyor strip is spiral wrapped around said product drum; and

a reservoir of said biologically active agent formulation adapted to cooperate with said product drum to transfer at least one application of said biologically active agent onto said microprojections after said protective layer is removed from said conveyor strip and as said conveyor strip travels around said product drum.

26. The system of claim 25, wherein said conveyor strip has a plurality of said microprojection members mounted thereon.

27. The system of claim 25, wherein at least two applications of said biologically active agent are transferred to said microprojections.

28. The system of claim 26, further including a drying chamber adapted to receive said conveyor strip carrying said microprojection members after transfer of said biologically active agent formulation to said microprojections.

29. The system of claim 26, further including a cutter to cut individual microprojection members from said conveyor strip.

30. A method for applying a biologically active agent formulation to a microprojection member having a plurality of stratum corneum-piercing microprojections, comprising the steps of:

providing a flexible conveyor strip having an adhesive layer and a substantially continuous protective layer removably disposed thereon, said microprojection member being disposed on said adhesive layer between said protective layer and said adhesive layer;

removing said protective layer from said conveyor strip;

spiral wrapping said conveyor strip around a product drum; and

conveying said microprojection member past a reservoir of said biologically active agent formulation to transfer at least one application of said biologically active agent onto said microprojections as said conveyor strip travels around said product drum.

31. The method of claim 30, wherein at least two applications of said biologically active agent are transferred to said microprojections.

32. The method of claim 30, wherein said product drum further includes a spiral flight configured to constrain said conveyor strip in a spiral wrap pattern.

33. The method of claim 32, wherein said product drum further includes a plurality of air holes on a surface of said product drum between said spiral flight, further comprising the step of delivering compressed air through said air holes to reduce friction between said conveyor strip and said product drum.

34. The method of claim 30, wherein said reservoir further comprises a biologically active agent formulation holding surface positioned relative to said product drum so that said microprojection member is conveyed past said reservoir with said microprojections being immersed at a predetermined level through said agent formulation on said holding surface.

35. The method of claim 34, wherein said biologically active agent formulation holding surface comprises a cylindrically-shaped coating drum, further comprising the steps of applying a film of said biologically active agent formulation to said holding surface and rotating said coating drum.

36. The method of claim 35, wherein said step of applying a film of said biologically active agent formulation to said holding surface comprises rotating said coating drum while said coating drum is partially immersed in a container of said biologically active agent formulation.

37. The method of claim 30, further including the step of applying a coating of biologically active agent to multiple microprojection members by providing said conveyor strip with a plurality of said microprojection members mounted thereon.