Antidepressant dosage form

• US 20070009600A1
• Filed: 09/15/2006
• Published: 01/11/2007
• Est. Priority Date: 05/27/1993
• Status: Active Grant

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Hatamkhani, Zahedeh, Wong, Patrick, Bhatti, Gurdish, Edgren, David
• Granted Patent: US 8,084,059 B2
• Time in Patent Office: Days
• US Class Current: 424/473
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/26 Psychostimulants, e.g. nicotine, cocaine

Abstract

The invention pertains to a dosage form 10 and to administering an antidepressant medicament 16 for an extended period of time in a rate-known dose.

Claims

1. A dosage form for delivering 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol having both controlled release and immediate release properties, the dosage form comprising:

(a) a wall comprising at least in part a composition permeable to the passage of fluid, but not to 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol, which wall surrounds;

(b) a compartment;

(c) a drug composition in the compartment comprising 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol;

(d) a displacement composition in the compartment comprising an osmotically active compound;

(e) an exit passageway in the dosage form for delivering the drug composition from the dosage form; and

(f) an external coat on the exterior of the wall that provides instant release of a drug for instant therapy, the drug comprising 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol, and hydroxypropylmethylcellulose.

2. The dosage form of claim 1, wherein the drug composition further comprises hydroxypropylmethylcellulose.

3. The dosage form of claim 1, wherein the drug composition weighs about 25% more than the displacement composition.