Manufacturing process, such as three dimensional printing, including binding of water-soluble material followed by softening and flowing and forming films of organic-solvent-soluble material
First Claim
1. A biostructure which comprises an organic-solvent-soluble network comprising organic-solvent-soluble material at least some of which is in the form of irregularly shaped perforated films, and wherein the organic-solvent-soluble material comprises an Active Pharmaceutical Ingredient and an organic-solvent-soluble material which is not an Active Pharmaceutical Ingredient.
5 Assignments
0 Petitions
Accused Products
Abstract
The invention includes biostructures which may be characterized as having substantially all of the organic-solvent-soluble material in the form of a network of irregularly shaped perforated films. The biostructure may further include particles of a substantially-insoluble material, which may be a member of the calcium phosphate family. The biostructure may be osteoconductive. The biostructure may further contain an Active Pharmaceutical Ingredient or other bioactive substance. The API may be a substance which stimulates the production of bone morphogenetic protein, such as Lovastatin or related substances, thereby making the biostructure effectively osteoinductive. One or more of the polymers may have a resorption rate in the human body such as to control the release of the API. Methods of manufacture are also disclosed.
-
Citations
37 Claims
- 1. A biostructure which comprises an organic-solvent-soluble network comprising organic-solvent-soluble material at least some of which is in the form of irregularly shaped perforated films, and wherein the organic-solvent-soluble material comprises an Active Pharmaceutical Ingredient and an organic-solvent-soluble material which is not an Active Pharmaceutical Ingredient.
- 17. A preform which comprises a water-soluble structure forming a network, and, partially attached to the water-soluble structure, particles of an organic-solvent-soluble material, the preform having macroscopic channels therethrough, wherein the organic-solvent-soluble material comprises an Active Pharmaceutical Ingredient.
- 19. A preform which comprises a water-soluble structure forming a network, and an irregularly-shaped perforated film of organic-solvent-soluble material conforming to surfaces of the water-soluble structure, wherein the organic-solvent-soluble material comprises an Active Pharmaceutical Ingredient.
-
21. A method of manufacturing a biostructure, the method comprising:
-
forming at least one powder mixture by mixing particles of an organic-solvent-soluble material and particles of a water-soluble material;
manufacturing a preform by causing particles of the water-soluble material in the powder mixture to join or adhere to other particles of the water-soluble material to form a water-soluble structure which also contains or holds particles of the organic-solvent-soluble material;
forming a film of the organic-solvent-soluble material by causing particles of the organic-solvent-soluble material to soften and at least partially flow to conform to surfaces of the water-soluble structure; and
causing or allowing the organic-solvent-soluble material to harden, wherein forming the film of the organic-solvent-soluble material comprises exposing the preform to a fluid in a supercritical or critical state or at a pressure greater than half the critical pressure of the fluid, under suitable conditions and for a suitable time duration to cause organic-solvent-soluble material in the preform to soften and at least partially flow. - View Dependent Claims (22)
-
-
23. (canceled)
-
24. A method of manufacturing a biostructure, the method comprising:
-
forming at least one powder mixture by mixing particles of an organic-solvent-soluble material and particles of a water-soluble material;
manufacturing a preform by causing particles of the water-soluble material in the powder mixture to join or adhere to other particles of the water-soluble material to form a water-soluble structure which also contains or holds particles of the organic-solvent-soluble material;
forming a film of the organic-solvent-soluble material by exposing the preform to a vapor of an organic solvent in which the organic-solvent-soluble material is soluble, under suitable conditions and for a suitable time duration to cause organic-solvent-soluble material in the preform to soften and at least partially flow to conform to surfaces of the water-soluble structure;
causing or allowing enough of the organic solvent to escape from the preform so that the organic-solvent-soluble material hardens; and
exposing the preform to a clean-up solvent suitable to remove residual organic solvent, wherein the clean-up solvent comprises carbon dioxide in a pressurized liquid, pressurized gas, critical or supercritical state.
-
-
25. A method of manufacturing a biostructure, the method comprising:
-
forming at least one powder mixture by mixing particles of an organic-solvent-soluble material and particles of a water-soluble material;
manufacturing a preform by causing particles of the water-soluble material in the powder mixture to join or adhere to other particles of the water-soluble material to form a water-soluble structure which also contains or holds particles of the organic-solvent-soluble material;
forming a film of the organic-solvent-soluble material by causing particles of the organic-solvent-soluble material to soften and at least partially flow to conform to surfaces of the water-soluble structure; and
causing or allowing the organic-solvent-soluble material to harden, wherein the organic-solvent-soluble material comprises an Active Pharamaceutical Ingredient. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
-
Specification