×

Methods and reagents for the treatment of immunoinflammatory disorders

  • US 20070010502A1
  • Filed: 09/07/2006
  • Published: 01/11/2007
  • Est. Priority Date: 10/15/2003
  • Status: Active Grant
First Claim
Patent Images

1. A method for treating a patient who has an immunoinflammatory disorder or is at risk for developing an immunoinflammatory disorder, said immunoinflammatory disorder selected from the group consisting of acne vulgaris;

  • acute respiratory distress syndrome;

    Addison'"'"'s disease;

    allergic rhinitis;

    allergic intraocular inflammatory diseases;

    ANCA-associated small-vessel vasculitis;

    arthritis, asthma;

    atherosclerosis;

    atopic dermatitis;

    autoimmune hemolytic anemia;

    autoimmune hepatitis;

    Behcet'"'"'s disease;

    Bell'"'"'s palsy;

    bullous pemphigoid;

    cerebral ischaemia;

    chronic obstructive pulmonary disease;

    cirrhosis;

    Cogan'"'"'s syndrome;

    contact dermatitis;

    COPD;

    Cushing'"'"'s syndrome;

    dermatomyositis;

    discoid lupus erythematosus;

    eosinophilic fasciitis;

    erythema nodosum;

    exfoliative dermatitis;

    focal glomerulosclerosis;

    giant cell arteritis;

    gout;

    gouty arthritis;

    graft-versus-host disease;

    hand eczema;

    Henoch-Schonlein purpura;

    herpes gestationis;

    hirsutism;

    idiopathic cerato-scleritis;

    idiopathic pulmonary fibrosis;

    idiopathic thrombocytopenic purpura;

    inflammatory bowel or gastrointestinal disorders, lichen planus;

    lupus nephritis;

    lymphomatous tracheobronchitis;

    macular edema;

    myasthenia gravis;

    myositis;

    osteoarthritis;

    pancreatitis;

    pemphigoid gestationis;

    pemphigus vulgaris;

    polyarteritis nodosa;

    polymyalgia rheumatica;

    pruritus scroti;

    pruritis/inflammation, psoriatic arthritis;

    relapsing polychondritis;

    rosacea;

    sarcoidosis;

    segmental glomerulosclerosis;

    septic shock syndrome;

    shoulder tendinitis or bursitis;

    Still'"'"'s disease;

    Sweet'"'"'s disease;

    Takayasu'"'"'s arteritis;

    temporal arteritis;

    toxic epidermal necrolysis;

    tuberculosis;

    uveitis;

    vasculitis; and

    Wegener'"'"'s granulomatosis;

    said method comprising administering to said patient;

    (a) a corticosteroid; and

    (b) a compound having the formula;

    embedded imagewherein each Z and each Z′

    is, independently, N, O, C, embedded imagewherein when Z or Z′

    is O or embedded imagethen p=1, when Z or Z′

    is N, embedded imagethen p=2, when Z or Z′

    is C, then p=3;

    each R1 is, independently, X, OH, N-alkyl, a branched or unbranched alkyl group having 1 to 20 carbon atoms, a heterocycle, or, when p>

    1, two R1 groups from a common Z or Z′

    atom, in combination with each other, represent —

    (CY2)k

    , wherein k is an integer between 4 and 6, inclusive;

    each X is, independently, Y, CY3, C(CY3)3, CY2CY3, (CY2)1-5OY, CnY2n-1, wherein n=3-7 inclusively; and

    each Y is independently;

    H, F, Cl, Br, or I, wherein said compound and said corticosteroid are administered simultaneously or within 14 days of each other, in amounts and for a duration sufficient to treat said patient.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×