Internal biochemical sensing device
First Claim
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1. A device for detecting an analyte from within a patient'"'"'s body, comprising:
- an optical fiber having;
a first end; and
a second end configured to connect to an analyzer; and
a biosensing material attached to the first end comprising;
a polymer matrix; and
tubulin, that binds with a chemotherapeutic agent, covalently bound to the polymer matrix.
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Abstract
A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of time. The biosensing element is connected to an optical fiber terminating outside of the body. The optical fiber is also connected to an information analyzer. The information analyzer receives light from the reaction of fluorescent molecules in the biosensing element. The biosensing device can be used to detect and analyze the effectiveness of chemotherapy agents and molecules associated with various diseases.
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Citations
16 Claims
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1. A device for detecting an analyte from within a patient'"'"'s body, comprising:
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an optical fiber having;
a first end; and
a second end configured to connect to an analyzer; and
a biosensing material attached to the first end comprising;
a polymer matrix; and
tubulin, that binds with a chemotherapeutic agent, covalently bound to the polymer matrix. - View Dependent Claims (2, 3, 4, 5)
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6. A device for detecting an analyte from within a patient'"'"'s body, comprising:
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an optical fiber having;
a first end; and
a second end configured to connect to an analyzer; and
a biosensing material attached to the first end comprising;
a polymer matrix; and
at least one fluorescent molecule covalently bound to the polymer matrix that fluoresces upon binding with at least one molecule indicative of apoptosis. - View Dependent Claims (7, 8, 9, 10, 11)
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12. A method of detecting the effectiveness of a chemotherapy agent, comprising:
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a) implanting an optical fiber having an implanted and free end within the patient'"'"'s body such that the implanted end lies within a tumor and the free end protrudes from the patient'"'"'s body, wherein the implanted end comprises biosensing material;
b) delivering a chemotherapy agent to the patient'"'"'s body;
c) delivering light from an analyzer to the biosensing material through the optical fiber;
d) receiving light from the biosensing material through the optical fiber; and
e) analyzing the light that returns to the analyzer from the biosensing material;
wherein the biosensing material comprises;
a polymer matrix; and
at least one fluorescent molecule covalently bound to the polymer matrix and that fluoresces upon interaction with at least one molecule indicative of apoptosis. - View Dependent Claims (13, 14, 15, 16)
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Specification