Delivery of muscle relaxants through an inhalation route
First Claim
1. A composition for delivery of quinine consisting of a condensation aerosol a. formed by volatilizing a coating of quinine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of quinine and condensing the heated vapor of quinine to form condensation aerosol particles, b. wherein said condensation aerosol particles are characterized by less than 5% quinine degradation products, and c. the condensation aerosol has an MMAD of less than 3 microns.
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Abstract
The present invention relates to the delivery of muscle relaxants through an inhalation route. Specifically, it relates to aerosols containing muscle relaxants that are used in inhalation therapy. In a method aspect of the present invention, a muscle relaxant is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a muscle relaxant, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% muscle relaxant degradation products. In a kit aspect of the present invention, a kit for delivering a muscle relaxant through an inhalation route is provided which comprises: a) a coating of a muscle relaxant and b) a device for dispensing said coating a muscle relaxant as a condensation aerosol.
163 Citations
24 Claims
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1. A composition for delivery of quinine consisting of a condensation aerosol
a. formed by volatilizing a coating of quinine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of quinine and condensing the heated vapor of quinine to form condensation aerosol particles, b. wherein said condensation aerosol particles are characterized by less than 5% quinine degradation products, and c. the condensation aerosol has an MMAD of less than 3 microns.
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4. A composition for delivery of chlorzoxazone consisting of a condensation aerosol
a. formed by volatilizing a coating of chlorzoxazone on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of chlorzoxazone and condensing the heated vapor of chlorzoxazone to form condensation aerosol particles, b. wherein said condensation aerosol particles are characterized by less than 5% chlorzoxazone degradation products, and c. the condensation aerosol has an MMAD of less than 3 microns.
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7. A composition for delivery of carisprodol consisting of a condensation aerosol
a. formed by volatilizing a coating of carisprodol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of carisprodol and condensing the heated vapor of carisprodol to form condensation aerosol particles, b. wherein said condensation aerosol particles are characterized by less than 5% carisprodol degradation products, and c. the condensation aerosol has an MMAD of less than 3 microns.
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10. A composition for delivery of cyclobenzaprine consisting of a condensation aerosol
a. formed by volatilizing a coating of cyclobenzaprine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of cyclobenzaprine and condensing the heated vapor of cyclobenzaprine to form condensation aerosol particles, b. wherein said condensation aerosol particles are characterized by less than 5% cyclobenzaprine degradation products, and c. the condensation aerosol has an MMAD of less than 3 microns.
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13. A method of producing quinine in an aerosol form comprising:
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a. heating a coating of quinine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the quinine to form a heated vapor of the quinine, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the quinine comprising less than 5% quinine degradation products, and an aerosol having an MMAD of less than 3 microns.
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16. A method of producing chlorzoxazone in an aerosol form comprising:
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a. heating a coating of chlorzoxazone on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the chlorzoxazone to form a heated vapor of the chlorzoxazone, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the chlorzoxazone comprising less than 5% chlorzoxazone degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (17, 18)
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19. A method of producing carisiprodol in an aerosol form comprising:
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a. heating a coating of carisiprodol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the carisiprodol to form a heated vapor of the carisiprodol, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the carisiprodol comprising less than 5% carisiprodol degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (20, 21)
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22. A method of producing cyclobenzaprine in an aerosol form comprising:
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a. heating a coating of cyclobenzaprine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the cyclobenzaprine to form a heated vapor of the cyclobenzaprine, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the cyclobenzaprine comprising less than 5% cyclobenzaprine degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (23, 24)
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Specification