Surface functionalization of polymeric materials

• US 20070014752A1
• Filed: 07/07/2006
• Published: 01/18/2007
• Est. Priority Date: 07/08/2005
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Roy, Krishnendu, Raja, Laxminariyan
• Application Number:
  US11/483,019
• Publication Number:
  US 20070014752A1
• Time in Patent Office: Days
• US Class Current: 424/78.80
• CPC Class Codes: A61K 47/6927 the form being a solid microparticle having no hollow or gas-filled cores
• CPC Class Codes: C08J 2367/04 Polyesters derived from hydroxy carboxylic acids, e.g. lactones C08J2367/06 takes precedence
• CPC Class Codes: C08J 3/128 Polymer particles coated by inorganic and non-macromolecular organic compounds
• CPC Class Codes: C08J 7/123 Treatment by wave energy or particle radiation C08J7/18 takes precedence

Abstract

The present invention relates to methods for functionalizing a surface, comprising exposing a surface of a polymeric material to an atmospheric pressure glow plasma discharge, wherein exposure to the plasma discharge functionalizes the surface of the polymeric material. The present invention further provides for methods for functionalizing a polymeric material, wherein the functionalized surface has conjugated thereto bioactive agents. The present invention is also directed to compositions comprising a functionalized surface with attached bioactive agents.

Claims

1. A method of functionalizing a polymeric material, which comprises exposing a surface of a polymeric material to an atmospheric pressure glow plasma discharge under conditions wherein exposure to the plasma discharge functionalizes the surface of the polymeric material.

2. The method of claim 1, wherein the polymeric material is a biodegradable polymer.

3. The method of claim 2, wherein the biopolymer is poly (lactide-co-glycolide) (PGLA).

4. The method of claim 1, wherein the polymeric material is a particle or a scaffold.

5. The method of claim 1, which comprises:

entraining the polymeric material into a gas phase to form a suspended polymeric material; and

introducing the suspended polymeric material into a volume of the atmospheric pressure glow plasma discharge.

6. The method of claim 5, which further comprises collecting the suspended polymeric material from the atmospheric pressure glow plasma discharge.

7. The method of claim 6, which further comprises loading the surface of the functionalized polymeric material with a bioactive agent.

8. The method of claim 7, wherein the bioactive agent is a protein.

9. A composition comprising a polymeric material having a surface that has been exposed to an atmospheric pressure glow plasma discharge resulting in the presence of charges or charged radical groups on the surface of the polymeric material.

10. The composition of claim 9, which further comprises a bioactive agent associated with the charges or charged radical groups on the surface of the polymeric material.

11. The composition of claim 10, wherein the bioactive agent comprises a small molecule drug, a protein drug, a peptide drug, a DNA drug, a RNA drug, an oligonucleotide drug, an immunomodulatory agent, a vaccine antigen, or a contrast or imaging agent.

12. The composition of claim 10, wherein the bioactive agent is a protein.

13. The composition of claim 9, wherein the polymeric material is a biodegradable polymer.

14. A composition comprising a polymeric material having an interior and having a surface that has been exposed to an atmospheric pressure glow plasma discharge resulting in the presence of charges or charged radical groups on the surface of the polymeric material.

15. The composition of claim 14, which further comprises:

a first bioactive agent associated with the charges or charged radical groups on the surface of the polymeric material; and

a second bioactive substance disposed within the interior of the polymeric material.

16. The composition of claim 14, wherein the polymeric material is a biodegradable polymer.

17. The composition of claim 16, wherein the polymeric particle is a biodegradable particle of poly(lactide-co-glycolide).

18. The composition of claim 15, wherein the first bioactive agent and the second bioactive agent comprises a small molecule drug, a protein drug, a peptide drug, a DNA drug, a RNA drug, an oligonucleotide drug, an immunomodulatory agent, a vaccine antigen, or a contrast or imaging agent.

19. The composition of claim 15, wherein the first bioactive agent comprises a vaccine antigen;

and the second bioactive agent comprises an immunomodulatory agent that regulates immune response to the vaccine antigen.

20. The composition of claim 15, wherein the polymeric material is a biopolymeric particle of poly(lactide-co-glycolide);

the first bioactive agent comprises a vaccine, and the second bioactive agent comprises an immunomodulatory agent that regulates immune response to the vaccine.