Solid pharmaceutical preparation containing levothyroxine and/or liothyronine salts
First Claim
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1. A solid pharmaceutical preparation comprising water-soluble salts of one or more selected from the group consisting of levothyroxine and liothyronine as an active ingredient wherein water activity of said pharmaceutical preparation is adjusted to values of below 0.4 and above 0.1, measured at room temperature.
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Abstract
In a solid pharmaceutical preparation containing water-soluble salts of levothyroxine and/or liothyronine as active ingredients, the water activity of said pharmaceutical preparation is adjusted to values of below 0.4 and, preferably, 0.1 to 0.3, measured at room temperature.
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Citations
24 Claims
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1. A solid pharmaceutical preparation comprising water-soluble salts of one or more selected from the group consisting of levothyroxine and liothyronine as an active ingredient
wherein water activity of said pharmaceutical preparation is adjusted to values of below 0.4 and above 0.1, measured at room temperature.
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8. A method for producing a pharmaceutical preparation comprising water-soluble salts of one or more selected from the group consisting of levothyroxine and liothyronine as an active ingredient, wherein water activity of said pharmaceutical preparation is adjusted to values of below 0.4 and above 0.1, measured at room temperature, comprising the steps of:
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applying to a carrier of mannitol an alcoholic solution of the active ingredient, evaporating until a water factor of below 0.4 and above 0.1 has been reached, and then tableting said preparation. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 19, 20, 21, 22, 23, 24)
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Specification