Nanoparticulate clarithromycin formulations
First Claim
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1. A stable nanoparticulate clarithromycin, or a salt or derivative thereof, composition comprising:
- (a) particles of clarithromycin, or a salt or derivative thereof, having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer.
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Abstract
The present invention is directed to compositions comprising nanoparticulate macrolides such as clarithromycin, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate macrolide particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of infection and related diseases.
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Citations
23 Claims
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1. A stable nanoparticulate clarithromycin, or a salt or derivative thereof, composition comprising:
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(a) particles of clarithromycin, or a salt or derivative thereof, having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of making a nanoparticulate clarithromycin, or a salt or derivative thereof, composition comprising:
- contacting particles of clarithromycin with at least one surface stabilizer for a time and under conditions sufficient to provide a nanoparticulate clarithromycin composition having an effective average particle size of less than about 2000 nm.
- View Dependent Claims (22)
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23. A method for treating a subject in need, wherein the subject is suffering from an infection or related condition, comprising:
- administering a therapeutically effective amount of a composition comprising;
(a) particles of clarithromycin, or a salt or derivative thereof, having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer.
- administering a therapeutically effective amount of a composition comprising;
Specification