2' and 3'-nucleoside prodrugs for treating Flaviviridae infections
First Claim
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof, of the formula:
6 Assignments
0 Petitions
Accused Products
Abstract
2′ and 3′-Prodrugs of 1′, 2′, 3′ or 4′-branched β-D or β-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
185 Citations
42 Claims
- 1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof, of the formula:
-
2. A compound of Formula II, or a pharmaceutically acceptable salt of the formula:
-
3. A compound of Formula III, or a pharmaceutically acceptable salt thereof:
-
4. A compound of Formula IV, or a pharmaceutically acceptable salt or prodrug thereof:
-
5. A compound of Formula V, or a pharmaceutically acceptable salt or prodrug thereof:
-
6. A compound of Formula VI or a pharmaceutically acceptable salt or prodrug thereof:
-
7. A compound selected from Formulas VII and VIII, or a pharmaceutically acceptable salt or prodrug thereof:
-
8. A compound of Formulas IX and X, or a pharmaceutically acceptable salt:
-
9. A compound selected from Formulas XI and XII, or a pharmaceutically acceptable salt thereof:
-
10. A compound of Formula XIII, or a pharmaceutically acceptable salt thereof:
Specification