Device and methods for the detection of locally-weighted tissue ischemia
First Claim
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1. A device for determining local ischemia in a target tissue, the device comprising:
- a broadband light source for illuminating the target tissue, wherein the broadband light source is selected such that light is substantially transmitted through capillaries in the target tissue while substantially absorbed through arterial and venous vessels in the target tissue, and for producing a transmitted light substantially representing the capillaries in the target tissue;
a sensor configured to detect light backscattered from the target tissue onto the sensor; and
a ischemia monitoring unit for generating, based on the light detected by the sensor, an output signal that is a function of the presence or degree of local ischemia in the target tissue.
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Abstract
An implantable ischemia detection device in which a broadband light source produces a continuous, visible, broadband light illuminating capillary sites within a well localized target tissue is provided. Light backscattered by the target tissue is collected by a sensor, allowing for an index of ischemia to be determined, and subsequently transmitted by a sending unit. Optionally, the device may be provided with an internal power source, the entire device encapsulated by a biocompatible shell to add long-term safety while implanted at a target tissue site.
130 Citations
16 Claims
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1. A device for determining local ischemia in a target tissue, the device comprising:
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a broadband light source for illuminating the target tissue, wherein the broadband light source is selected such that light is substantially transmitted through capillaries in the target tissue while substantially absorbed through arterial and venous vessels in the target tissue, and for producing a transmitted light substantially representing the capillaries in the target tissue;
a sensor configured to detect light backscattered from the target tissue onto the sensor; and
a ischemia monitoring unit for generating, based on the light detected by the sensor, an output signal that is a function of the presence or degree of local ischemia in the target tissue. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9, 10, 11)
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6. A method of detecting ischemia in a tissue, the method comprising:
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implanting a light emitting and detecting device at a target site;
illuminating the target site with locally-sampled visible light illumination from the light emitting and detecting device;
detecting light returning from the site using the light emitting and detecting device; and
determining a measure that is a function of ischemia based upon the detected light. - View Dependent Claims (12)
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13. An implantable medical device to detect local ischemia in a target tissue, the implantable medical device comprising:
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a broadband light source for illuminating the target tissue with light;
a sensor configured so as to detect light backscattered from the target tissue onto the sensor;
a transmitter configured to determine, based upon the light detected by the sensor, an output signal that is a function of the presence or degree of ischemia and to transmit the output signal; and
an exterior shell configured to be biocompatible with respect to implantation.
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14. An implantable medical device for detecting local ischemia in a target tissue, the implantable medical device comprising:
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a broadband light source for illuminating the target tissue with broadband light;
a sensor configured to detect light backscattered from the target tissue onto the sensor; and
means for determining the presence or absence of local ischemia in the target tissue based on the wavelength of the detected light.
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15. A method of detecting ischemia in a target tissue, the method characterized in that a light source selectively emits wavelengths of light to the target tissue such that the wavelengths are substantially transmitted through capillaries in the target tissue and substantially absorbed by arterial and venous vessels in the target tissue.
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16. A device for detecting ischemia in tissue, the device comprising a light source configured to selectively emit wavelengths of light to the target tissue such that the wavelengths are substantially transmitted through capillaries in the target tissue and substantially absorbed by arterial and venous vessels in the target tissue.
Specification