Imaging systems and methods to improve backscattering imaging using circular polarization memory

• US 20070016080A1
• Filed: 04/27/2006
• Published: 01/18/2007
• Est. Priority Date: 04/28/2005
• Status: Active Grant

• Current Assignee: City College of New York
• Original Assignee: City College of New York
• Inventors: Ni, Xiaohui, Alfano, Robert
• Granted Patent: US 7,515,265 B2
• Time in Patent Office: Days
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: G01N 2021/216 using circular polarised light
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

An optical technique to improve the imaging of a target inside suspensions of scattering particles includes the illumination of the scattering particles with circularly polarized light. The backscattered light from the host medium preserves the helicity of incident light, while the backscattered light reflected from the target is predominated with light of opposite helicity. Based on the observed helicity difference in the emerging light that originated at the target and that backscattered from the medium, the present optical technique improves the image contrast using circular polarization. This approach makes use of polarization memory which leads to the reflected light from the target accompanied by weak diffusive backscattered light. Using the present technique, improved imaging of the artery wall is achieved and plaque composition can be assessed through a blood field associated with the artery. The scattering from the particles, such as red blood cells, in the blood is reduced due to polarization memory. The present invention can be also applied to other biomedical application, as well as image targets through adverse environmental conditions, such as fog, clouds, smoke, murky water, etc.

Claims

1. A method for analyzing an object located in a turbid medium comprising the steps of:

illuminating the object through the turbid medium with circularly polarized light such that backscattered light emerges from the illuminated turbid medium;

passing the backscattered light through a first device to select out backscattered light that has an opposite helicity relative to the incident polarization; and

detecting the backscattered light with opposite helicity that passes through the first device to permit detection of the object;

wherein particles within the turbid medium have a dimension (a) that is greater than the wavelength (λ

) of the backscattered light.

2. The method as claimed in claim 1, wherein the first device is selected from the group consisting of (a) a retardation λ

/4 plate and a linear polarizer and (b) a circular polarizer.

3. The method as claimed in claim 1, wherein the step of detecting the backscattered light is performed over an area using a detector selected from the group consisting of:

a photomultiplier, a photodiode, a CCD camera, and a photodetector to permit at least one of an light intensity profile or an image of the object to be achieved.

4. The method as claimed in claim 1, wherein the step of detecting the backscattered light is performed point-by-point using one of a photomultiplier, a photodiode and a photodetector.

5. The method as claimed in claim 1, wherein the polarized backscattered light that emerges from the turbid medium has a wavelength that exhibits minimum absorption in turbid medium.

6. The method as claimed in claim 1, wherein the turbid medium is a tissue sample.

7. The method as claimed in claim 6, wherein the tissue sample is a human tissue sample.

8. The method as claimed in claim 7, wherein the human tissue sample is selected from the group consisting of human breast tissue, human brain tissue, human prostate tissue, human liver tissue, human skin tissue, human gastrointestinal tissue, human mucosa tissue, human GYN tissue, human under-arm glandular tissue, human kidney tissue and cells in tissues.

9. The method as claimed in claim 1, wherein the turbid medium is an atmospheric environment.

10. The method as claimed in claim 9, wherein the atmospheric environment comprises one of aerosols, heavy fog, and cumulus conditions.

11. The method as claimed in claim 1, wherein the turbid medium is surgical smoke generated during performance of a surgical operation.

12. The method of claim 1, wherein the dimension (a) of the particles is from about 1 to about 20 times the wavelength (λ

).

13. The method of claim 1, further including the step of:

processing the detected backscattered light with opposite helicity to provide a displayable image of the target.

14. A method for analyzing coronary lesions, such as vulnerable plaques inside the walls of the arteries, comprising the steps of:

directing near-infrared circularly polarized light onto a target blood vessel with an optical instrument;

illuminating a wall of the vessel that contains blood flow;

detecting backscattered light from the artery wall and from objects within the blood vessel, the detected backscattered light having an opposite helicity relative to incident polarization; and

analyzing the backscattered light with opposite helicity from the artery.

15. The method as claimed in claim 14, wherein the step of detecting the backscattered light is performed over an area using one of a photomultiplier, a photodiode, a CCD camera and a photodetector to determine and locate plaque.

16. The method as claimed in claim 14, wherein the step of detecting the backscattered light is performed point-by-point using one of a photomultiplier, a photodiode and a photodetector.

17. A method as claimed in claim 14, wherein a surface of the artery wall is imaged through a blood field using circularly polarized light of opposite helicity with a wavelength less than 1 μ

m.

18. The method as claimed in claim 14, further including the step of:

imaging the wall of artery for plaque by at least one optical method selected from the group consisting of OCT, Raman, fluorescence, absorption, scattering, or emission.

19. The method as claimed in claim 14, wherein the step of analyzing the backscattered light with opposite helicity from the artery includes the steps of:

directing the backscatter light opposite helicity to a detector;

processing the detected backscattered light with opposite helicity by means of the detector to provide a displayable image of the target.

20. An optical system for imaging a target located within a suspension of scattering particles that at least in part define a turbid medium comprising:

a light source producing parallel polarized light;

a first device for converting the parallel polarized light to circularly polarized light having a first handedness;

an optical instrument that illuminates the target with the circularly polarized light resulting in backscattered light being formed that comprises circularly polarized light having the first handedness and circularly polarized light having an opposite second handedness which are collected by a probe of the instrument;

a second device for converting the circularly polarized light having the first handedness into parallel polarized light and the circularly polarized light having the second handedness into perpendicular polarized light; and

a third device that is configured to select out the perpendicular polarized light for detection by a detector that is configured to process the perpendicular polarized light and provide displayable information concerning the target;

wherein a dimension of the scattering particles is greater than a wavelength (λ

) of the circularly polarized backscattered light.

21. The system of claim 20, wherein the circularly polarized light having a first handedness comprises right-handed circularly polarized light and the circularly polarized light having a second handedness comprises left-handed circularly polarized light.

22. The system of claim 20, wherein the light source comprises a laser.

23. The system of claim 20, wherein the optical instrument comprises an optical catheter that is communication with the first and second polarizing devices via a flexible optical carrier and the probe is a fiber optic probe integrated with the catheter.

24. The system of claim 20, wherein the first device comprises a first polarizer and a quarter-wave plate that is located optically downstream from the first polarizer.

25. The system of claim 20, wherein the second device includes a quarter-wave plate.

26. The system of claim 20, wherein the third device comprises an analyzer that is located perpendicular to a first polarizer that is part of the first device.

27. The system of claim 20, wherein the detector is device that is selected from the group consisting of a photomultiplier, a photodiode, a CCD camera and a photodetector.

28. The system of claim 20, wherein the detector is a CCD camera that is configured to process the perpendicular polarized light and provide a displayable image of the target.

29. The system of claim 20, wherein the dimension of the scattering particles is a diameter of the particles and the diameter is in a range from about 1 to about 20 times the wavelength of the light.

30. The system of claim 20, the wavelength (λ

) is from about 0.8 μ

m to about 1.4 μ

m.

31. The system of claim 20, wherein the target comprises plaque that is present along an artery wall and the scattering particles includes blood particles.

32. A system for imaging a target that is located within a turbid medium that is defined in part by a suspension of scattering elements that have a dimension (a) comprising:

a light source producing polarized light;

a first device for converting the polarized light to circularly polarized light;

an instrument operatively and optically connected to the light source and configured to illuminate the element with the circularly polarized light and to collect circularly polarized backscattered light that is formed;

a second device for converting the circularly polarized backscattered light into copolarized light and cross-polarized light relative to the polarized light of the light source;

a third device for filtering out the cross-polarized light from the copolarized light; and

a fourth device for receiving and processing the filtered cross-polarized light and record graphic images of the target, wherein the filtered cross-polarized light has a wavelength (λ

) less than the dimension (a) of the scattering elements.

33. The system of claim 32, wherein the instrument is constructed and dimensioned to be received within a blood vessel.

34. The system of claim 32, wherein the light source generates parallel polarized light and the coplanarized light is parallel polarized light, while the cross-polarized light is perpendicular polarized light.

35. The system of claim 32, wherein the first device generates right-handed circularly polarized light and the backscattered light comprises both right-handed circularly polarized light and left-handed circularly polarized light that is converted to perpendicular polarized light by the second device.

36. The system of claim 33, wherein the instrument comprises an optical catheter that is communication with the first and second devices via a flexible optical carrier and includes a fiber optic probe integrated with the catheter that collects the backscattered light and supports the fourth device so that a graphic image of the target can be displayed.

37. The system of claim 32, wherein the first device comprises a first polarizer and a quarter-wave plate that is located optically downstream from the first polarizer.

38. The system of claim 32, wherein the second device comprises a quarter-wave plate.

39. The system of claim 32, wherein the third device comprises an analyzer that is located perpendicular to a first polarizer that is part of the first device.