Neurotransmitter stimulation of neurons with feedback from sensors
First Claim
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1. A system for performing neurotransmitter stimulation of neurons, comprising:
- an actuated system for the chemical stimulation of neurons comprising at least one synthetic reservoir having at least one aperture and an actuation means for controlling a release of neurotransmitter molecules through the at least one aperture of the at least one synthetic reservoir, wherein the reservoir comprises neurotransmitter molecules; and
a feedback system comprising at least one sensor, wherein the actuation means is controlled by the feedback system.
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Abstract
The present invention provides a system for the release of neurotransmitters and a method for the manufacturing of such a system. The system according to the present invention allows for local release of neurotransmitters and therefore makes it possible to activate single neurons. Furthermore, the system according to the invention is efficient, reproducible, and has a low power supply.
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Citations
22 Claims
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1. A system for performing neurotransmitter stimulation of neurons, comprising:
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an actuated system for the chemical stimulation of neurons comprising at least one synthetic reservoir having at least one aperture and an actuation means for controlling a release of neurotransmitter molecules through the at least one aperture of the at least one synthetic reservoir, wherein the reservoir comprises neurotransmitter molecules; and
a feedback system comprising at least one sensor, wherein the actuation means is controlled by the feedback system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for the manufacturing a system for performing neurotransmitter stimulation of neurons, comprising:
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providing at least one synthetic reservoir for containing neurotransmitter molecules, wherein the at least one synthetic reservoir has at least one aperture;
providing an actuation means for controlling a release of the neurotransmitter molecules through the at least one aperture of the at least one synthetic reservoir; and
providing a feedback means for controlling the actuation means. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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21. In a system for performing neurotransmitter stimulation of neurons comprising an actuated system for the chemical stimulation of neurons comprising at least one synthetic reservoir having at least one aperture and an actuation means for controlling a release of neurotransmitter molecules through the at least one aperture of the at least one synthetic reservoir, wherein the reservoir comprises neurotransmitter molecules, and a feedback system comprising at least one sensor, wherein the actuation means is controlled by the feedback system, a method for determining a control signal for controlling the actuation means, comprising:
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detecting neuron activity in the form of neuronal signals;
comparing the neuronal signals with a pre-determined threshold voltage; and
from this comparison, determining the control signal for the actuation means.
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22. In a system for performing neurotransmitter stimulation of neurons comprising an actuated system for the chemical stimulation of neurons comprising at least one synthetic reservoir having at least one aperture and an actuation means for controlling a release of neurotransmitter molecules through the at least one aperture of the at least one synthetic reservoir, wherein the reservoir comprises neurotransmitter molecules, and a feedback system comprising at least one sensor, wherein the actuation means is controlled by the feedback system, a system for determining a control signal for controlling the actuation means, comprising:
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a processor;
data storage; and
machine language instructions stored in the data storage executable by the processor to;
detect neuron activity in the form of neuronal signals;
compare the neuronal signals with a predetermined threshold voltage; and
from this comparison, determine the control signal for the actuation means.
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Specification