Methods, systems, and computer program products for optimization of probes for spectroscopic measurement in turbid media
First Claim
1. A method for optimizing a probe geometry for spectroscopic measurement in a turbid medium, the method comprising:
- (a) selecting a probe geometry comprising at least one emitting entity for emitting electromagnetic radiation into a turbid medium and at least one collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium;
(b) performing a simulation with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values;
(c) providing the measured optical parameter values as input to an inversion algorithm and thereby producing corresponding optical properties as output;
(d) comparing the produced optical properties with optical properties known to correspond to the measured optical parameter values and determining a degree of matching between the produced and known optical properties;
(e) repeating steps (b)-(d) for a plurality of additional probe geometries, wherein each additional probe geometry differs from the probe geometry of step (a) in at least one property selected from the group consisting of a quantity of collecting entities, a diameter of at least one collecting entity, a linear distance between the emitting entity and the collecting entity, and combinations thereof, wherein repeating steps (b)-(d) comprises, at each iteration, applying an optimization algorithm to select a probe geometry such that the resulting degree of matching will converge to an optimum value; and
(f) selecting from among the different probe geometries, an optimal geometry based on the degree of matching determined for each geometry in step (d).
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Abstract
The presently disclosed subject matter provides methods, systems, and computer program products for optimizing a probe geometry for spectroscopic measurement in a turbid medium. According to one method, a probe geometry comprising one emitting entity for emitting electromagnetic radiation into a turbid medium and at least on collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium is selected. A simulation is performed with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values. The measured optical parameter values are input to an inversion algorithm to produce corresponding optical properties as output. The produced optical properties are compared with optical properties known to correspond to the measured optical parameter values and a degree of matching between the produced optical properties and the known optical properties is determined. The simulation and inversion steps are repeated for a plurality of additional probe geometries. Each additional probe geometry differs from the previously tested probe geometry in at least one property. The property may be a quantity of collecting entities, a diameter of at least one emitting or collecting entity, a linear between the emitting and collecting entities, or combinations thereof. An optimization algorithm is applied at each iteration to select a probe geometry such that the resulting degree of matching will converge to an optimum value. An optimal geometry is selected based on the degree of matching determined for each geometry.
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Citations
31 Claims
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1. A method for optimizing a probe geometry for spectroscopic measurement in a turbid medium, the method comprising:
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(a) selecting a probe geometry comprising at least one emitting entity for emitting electromagnetic radiation into a turbid medium and at least one collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium;
(b) performing a simulation with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values;
(c) providing the measured optical parameter values as input to an inversion algorithm and thereby producing corresponding optical properties as output;
(d) comparing the produced optical properties with optical properties known to correspond to the measured optical parameter values and determining a degree of matching between the produced and known optical properties;
(e) repeating steps (b)-(d) for a plurality of additional probe geometries, wherein each additional probe geometry differs from the probe geometry of step (a) in at least one property selected from the group consisting of a quantity of collecting entities, a diameter of at least one collecting entity, a linear distance between the emitting entity and the collecting entity, and combinations thereof, wherein repeating steps (b)-(d) comprises, at each iteration, applying an optimization algorithm to select a probe geometry such that the resulting degree of matching will converge to an optimum value; and
(f) selecting from among the different probe geometries, an optimal geometry based on the degree of matching determined for each geometry in step (d). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A probe for generating and collecting electromagnetic radiation that interacts with a turbid medium, the probe comprising:
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(a) at least one emitting entity for emitting electromagnetic radiation into a turbid medium; and
(b) at least two collecting the electromagnetic radiation emitted by the emitting entity that has interacted with the turbid medium, wherein a linear distance between the emitting entity and each collecting entity does not exceed 1.5 millimeters and wherein the linear distance is determined using an optimization algorithm that optimizes measurement accuracy of the probe with regard to at least one optical property of a turbid medium. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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28. A system for selecting an optimal geometry for a probe for spectroscopic measurement in turbid media, the system comprising:
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(a) a light transport model for receiving as inputs a probe geometry and a plurality of sets of optical properties of a turbid medium and for producing as output optical parameter values that would be measured by the probe geometry for each set of input optical properties;
(b) an objective function for implementing an inversion algorithm for receiving as input the measured optical parameter values, for producing corresponding optical properties, for comparing the produced optical properties with optical properties known to correspond to the measured optical parameter values, and for determining a degree of matching between the produced and known optical properties for the given probe geometry, wherein the light transport model and the inversion algorithm are adapted to test a plurality of different probe geometries and wherein the inversion algorithm is adapted to determine a degree of matching between the produced and known optical properties for each geometry; and
(c) a probe selector for selecting one of the geometries as an optimal geometry based the degree of matching associated with the selected geometry. - View Dependent Claims (29, 30)
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31. A computer program product comprising computer executable instructions embodied in computer readable medium for performing steps comprising:
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(a) selecting a probe geometry comprising at least one emitting entity for emitting electromagnetic radiation into a turbid medium and at least one collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium;
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(b) performing a simulation with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values;
(c) providing the measured optical parameter values as input to an inversion algorithm and thereby producing corresponding optical properties as output;
(d) comparing the produced optical properties with optical properties known to correspond to the measured optical parameter values and determining a degree of matching between the produced and known optical properties;
(e) repeating steps (b)-(d) for a plurality of additional probe geometries, wherein each additional probe geometry differs from the probe geometry of step (a) in at least one property selected from the group consisting of a quantity of collecting entities, a diameter of at least one emitting or collecting entity, a linear distance between the emitting and collecting entities, and combinations thereof, wherein repeating steps (b)-(d) comprises, at each iteration, applying an optimization algorithm to select a probe geometry such that the resulting degree of matching will converge to an optimum value; and
(f) selecting, from among the different probe geometries, an optimal geometry based on the degree of matching determined for each geometry in step (d).
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Specification