Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surfical planning
First Claim
25. A method for making corresponding measurements across individuals to characterize populations of patients and to classify the population to which a patient is likely to belong, the method comprising:
- (a) modeling blood vessels of a plurality of different individual patients;
(b) calculating a map of blood vessel characteristics for each model;
(c) establishing correspondence across individuals by aligning the models with the maps of blood vessel characteristics;
(d) based on the correspondences, forming population summaries of consistent measures for diseased and un-diseased groups; and
(e) using the population summaries to distinguish normal from abnormal measures.
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Accused Products
Abstract
Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surgical planning are disclosed. A method for analyzing blood vessel attributes may include developing an atlas including statistical measures for at least one blood vessel attribute. The statistical measures can be developed from blood vessel image data from different individuals. Blood vessel attribute measurements can be obtained from an individual subject. The individual subject'"'"'s blood vessel attribute measurements can be compared to the statistical measures in the atlas. Output may be produced indicative of a physical characteristic of the individual based on results from the comparison.
220 Citations
91 Claims
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25. A method for making corresponding measurements across individuals to characterize populations of patients and to classify the population to which a patient is likely to belong, the method comprising:
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(a) modeling blood vessels of a plurality of different individual patients;
(b) calculating a map of blood vessel characteristics for each model;
(c) establishing correspondence across individuals by aligning the models with the maps of blood vessel characteristics;
(d) based on the correspondences, forming population summaries of consistent measures for diseased and un-diseased groups; and
(e) using the population summaries to distinguish normal from abnormal measures. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33)
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34. A method for forming a vasculature atlas, the method comprising:
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(a) segmenting blood vessel image data for a plurality of different subjects that form a population having a common physical characteristic;
(b) creating a template comprising blurred blood vessel image data;
(c) registering the blood vessel image data for the individual subjects with the template and determining transforms based on the registration;
(d) blurring the blood vessel image data for each of the plurality of different subjects;
(e) applying the transforms to the blurred blood vessel image data for the individual subjects to produce blurred, transformed blood vessel image data for the individual subjects; and
(f) computing a statistical measure based on the blurred transformed, blood vessel image data for the individual subjects, wherein the statistical measure indicates a representative blood vessel attribute for the plurality of subjects. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41)
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42. A system for analyzing blood vessel attributes, the system comprising:
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(a) an atlas of blood vessel anatomy, the atlas including statistical measures for at least one blood vessel attribute, the statistical measures being developed from blood vessel image data from a plurality of different individuals;
(b) an attribute measurement module for obtaining a blood vessel attribute measurement for an individual subject;
(c) an individual subject attribute comparator for comparing the individual subject'"'"'s blood vessel attribute measurements to the statistical measurement in the atlas; and
(d) an output module for outputting results of the comparison. - View Dependent Claims (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 43, 44, 45, 46, 47, 48, 49)
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44-1. The system of claim 48 wherein the indicator comprises a z-score value.
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50. A computer program product comprising computer-executable instructions embodied in a computer-readable medium for performing steps comprising:
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(a) developing an atlas including statistical measures for at least one blood vessel attribute, the statistical measures being developed from blood vessel image data from a plurality of different individuals;
(b) obtaining blood vessel attribute measurements for an individual subject;
(c) comparing the individual subject'"'"'s blood vessel attribute measurements to the statistical measures in the atlas; and
(d) based on the comparison, determining a physical characteristic of the individual subject. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73)
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74. A computer program product comprising computer-executable instructions embodied in a computer-readable medium for performing steps comprising:
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(a) modeling blood vessels of a plurality of different individual patients;
(b) calculating a map of blood vessel characteristics for each model;
(c) establishing correspondence across individuals by aligning the models with the maps of blood vessel characteristics;
(d) based on the correspondences, forming population summaries of consistent measures for diseased and un-diseased groups; and
(e) using the population summaries to distinguish normal from abnormal measures. - View Dependent Claims (75, 76, 77, 78, 79, 80, 81, 82)
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83. A computer program product comprising computer-executable instructions embodied in a computer-readable medium for performing steps comprising:
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(a) segmenting blood vessel image data for a plurality of different subjects that form a population having a common physical characteristic;
(b) creating a template comprising blurred blood vessel image data;
(c) registering the blood vessel image data for the individual subjects with the template and determining transforms based on the registration;
(d) blurring the blood vessel image data for each of the plurality of different subjects;
(e) applying the transforms to the blurred blood vessel image data for the individual subjects to produce blurred, transformed blood vessel image data for the individual subjects; and
(f) computing a statistical measure based on the blurred transformed, blood vessel image data for the individual subjects, wherein the statistical measure indicates a representative blood vessel attribute for the plurality of subjects. - View Dependent Claims (84, 85, 86, 87, 88, 89, 90)
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91. A computer program product comprising computer-executable instructions embodied in a computer-readable medium for performing steps comprising:
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(a) receiving blood vessel image data for an individual subject;
(b) registering the blood vessel image data with an atlas of blood vessel image data;
(c) comparing corresponding anatomical regions between the individual subject'"'"'s blood vessel image data and the blood vessel image data of the atlas; and
(d) based on the comparison, determining whether the individual subject has a particular physical characteristic.
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Specification