Nasally administered appetite suppressants
First Claim
1. A method of treating obesity in a mammal in need of such treatment comprising applying a sodium channel blocker to the mammal intranasally and administering a second compound selected from either or both of an energy expenditure drug and an anorexiant to the mammal.
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Accused Products
Abstract
Methods are described for suppressing appetite through the intranasal administration of a sodium channel blocker. It has long been known that smell and taste are an important part of how the body prepares for a meal, for example the cephalic phase of insulin release before a meal. Depressing the sense of smell or taste in subjects prior to meals leads to decreased food intake, which ultimately leads to weight loss. The ability to deliver drugs to the CSF via intranasal application also provides anorexiant central effect.
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Citations
17 Claims
- 1. A method of treating obesity in a mammal in need of such treatment comprising applying a sodium channel blocker to the mammal intranasally and administering a second compound selected from either or both of an energy expenditure drug and an anorexiant to the mammal.
- 14. A method of treating obesity in a mammal in need of such treatment comprising applying a sodium channel blocker and a second compound selected from one or more of an energy expenditure drug, an anorexiant, a humectant, a pH buffer and a thickening agent to the mammal.
Specification