Oral composition containing non-aggregated zinc nanoparticles

• US 20070020201A1
• Filed: 07/21/2005
• Published: 01/25/2007
• Est. Priority Date: 07/21/2005
• Status: Active Grant

• Current Assignee: Cogate Palmolive Company, Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Xu, Guofeng, Gaffar, Abdul, Boyd, Thomas, Viscio, David, Fruge, Linh, Arvanitidou, Evangelia
• Granted Patent: US 9,242,125 B2
• Time in Patent Office: Days
• US Class Current: 424/52
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

An oral composition comprising a vehicle and a zinc ion source in the form of nanoparticles that are substantially non-aggregated and methods for use of such compositions are described. The composition provides antiplaque and anti malodor benefits to the user and the inclusion of nanoparticles permits a reduction in the amount of zinc ions present in the composition while maintaining efficacy.

Claims

1. An oral composition comprising a vehicle and a zinc ion source in the form of nanoparticles that are substantially non-aggregated.

2. The oral composition of claim 1, wherein about more than 90% of the nanoparticles are non-aggregated.

3. The oral composition of claim 1, wherein about more than 80% of the nanoparticles are non-aggregated.

4. The oral composition of claim 1, wherein the zinc ion source in the form of nanoparticles is present in an amount of less than about 1% by weight.

5. The oral composition of claim 4, wherein size of the nanoparticles is about 1 to about 250 nm.

6. The oral composition of claim 1, wherein the zinc ion source is zinc oxide.

7. The oral composition of claim 1, wherein the oral composition further comprises one or more therapeutic agents.

8. The oral composition of claim 7, wherein the therapeutic agent is selected from an anticaries agent and antibacterial agent.

9. The oral composition of claim 8, wherein the therapeutic agent is selected from the group consisting of triclosan, stannous ion, fluoride, arginine salts, and cetyl pyrinidium salts, honokiol and magnolol.

10. The oral composition of claim 1, wherein the oral composition further comprises an ingredient selected from the group consisting of an abrasive, a surfactant, a flavor agent, and a sweetener.

19. A method of maintaining or promoting health of human or animal comprising:

administering to the oral cavity an effective amount of the composition of claim 1.

20. The method of claim 19, wherein the composition is in a form selected from the group consisting of mouthwash, oral strip, toothpaste, liquid whitener, chewing gum, bead, chew, lozenge and spray.

11. A film comprising a zinc ion source in the form of nanoparticles which are substantially non-aggregated.

12. The film of claim 11, wherein the zinc ion source in the form of nanoparticles is present in an amount of less than about 25% by weight.

13. The film of claim 11, wherein size of the nanoparticles is about 1 to about 250 nm.

14. The film of claim 11, wherein the zinc ion source is zinc oxide.

15. The film of claim 11, wherein the oral composition further comprises one or more therapeutic agents.

16. A dentifrice comprising the film of claim 11.

17. An oral care article comprising an orally acceptable vehicle and less than about 1% by weight of zinc oxide nanoparticles which are substantially non-aggregated, wherein the oral care article is selected from the group consisting of mouthwash, oral strip, toothpaste, liquid whitener, chewing gum, bead, chew, lozenge and spray.

18. The oral care article of claim 17, wherein size of the nanoparticles is about 1 to about 250 nm.

21. An oral composition comprising

a vehicle

a zinc ion source in the form of nanoparticles which are substantially non-aggregated, and triclosan.