OB fusion protein compositions and methods
First Claim
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1. A protein having a formula selected from the group consisting of:
- R1—
R2 and R1-L-R2, wherein R1 is a Fc protein or analog thereof, R2 is an OB protein or analog thereof, and L is a linker.
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Abstract
The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or chemical fusion protein comprising the Fc immunoglobulin region, derivative or analog fused to the N-terminal portion of the OB protein, derivative or analog.
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Citations
19 Claims
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1. A protein having a formula selected from the group consisting of:
- R1—
R2 and R1-L-R2, wherein R1 is a Fc protein or analog thereof, R2 is an OB protein or analog thereof, and L is a linker. - View Dependent Claims (2, 3, 4, 5, 16, 17, 18, 19)
- R1—
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6. A fusion protein comprising a Fc protein, analog or derivative thereof, fused to the N-terminus of an OB protein, analog or derivative thereof.
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7. A nucleic acid sequence encoding for a protein having a formula selected from the group consisting of:
- R1—
R2 and R1-L-R2, wherein R1 is a Fc protein or analog thereof, R2 is an OB protein or analog thereof, and L is a linker. - View Dependent Claims (8, 9, 10, 11, 13, 14, 15)
- R1—
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12. A nucleic acid sequence encoding for a fusion protein having a Fc protein, analog or derivative thereof, fused to the N-terminus of an OB protein, analog or derivative thereof.
Specification