Modulation of HIF1alpha and HIF2alpha expression
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Abstract
Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
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Citations
134 Claims
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1-115. -115. (canceled)
- 116. An antisense oligonucleotide 12 to 50 nucleobases in length targeted to at least a portion of nucleotides 2821 to 2859 of a nucleic acid molecule encoding HIF1α
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129. An antisense oligonucleotide 16, 17, 18, 19, 20, 21, 22, 23, 24 or 25 nucleobases in length targeted to a nucleic acid molecule encoding HIF1α
- (SEQ ID NO;
133), wherein said antisense oligonucleotide has at least 80% identity with SEQ ID NO;
189. - View Dependent Claims (130, 131)
- (SEQ ID NO;
- 132. An antisense oligonucleotide with a nucleotide sequence consisting of SEQ ID NO:
Specification