INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
28 Citations
79 Claims
-
1-7. -7. (canceled)
-
8. An isolated or recombinant polypeptide comprising a sequence which
(a) differs in 0 to 16 amino acid positions from SEQ ID NO: - 13 and
(b) comprises Ala or Leu at position 48;
which polypeptide exhibits antiviral activity. - View Dependent Claims (9, 10, 74)
- 13 and
-
11. An isolated or recombinant polypeptide comprising the sequence SEQ ID NO:
- 13, optionally further comprising a methionine at the N-terminus, which polypeptide exhibits antiviral activity.
- View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 46, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73)
-
12-19. -19. (canceled)
-
20. An isolated or recombinant polypeptide comprising a sequence which
(a) differs in 0 to 16 amino acid positions from SEQ ID NO: - 38 and
(b) comprises Ala or Leu at position 48;
which polypeptide exhibits antiviral activity. - View Dependent Claims (21, 22, 75)
- 38 and
-
23. An isolated or recombinant polypeptide comprising the sequence SEQ ID NO:
- 38 or the sequence of a variant thereof wherein the variant differs in 1 to 2 amino acid positions from SEQ ID NO;
38, optionally further comprising a methionine at the N-terminus, which polypeptide exhibits antiviral activity. - View Dependent Claims (76)
- 38 or the sequence of a variant thereof wherein the variant differs in 1 to 2 amino acid positions from SEQ ID NO;
-
38. A conjugate comprising
(a) a polypeptide comprising the sequence SEQ ID NO: - 13, optionally further comprising a methionine at the N-terminus; and
(b) a PEG moiety covalently attached to a lysine residue of the polypeptide, which conjugate exhibits antiviral activity. - View Dependent Claims (39, 40, 47)
- 13, optionally further comprising a methionine at the N-terminus; and
-
41. A conjugate comprising
(a) a polypeptide comprising the sequence SEQ ID NO: - 38 or the sequence of a variant thereof wherein the variant differs in 1 to 2 amino acid positions from SEQ ID NO;
38, optionally further comprising a methionine at the N-terminus; and
(b) a PEG moiety covalently attached to a lysine residue of the polypeptide, which conjugate exhibits antiviral activity. - View Dependent Claims (42, 43, 78)
- 38 or the sequence of a variant thereof wherein the variant differs in 1 to 2 amino acid positions from SEQ ID NO;
-
44. A composition comprising
(a) a conjugate comprising a polypeptide comprising the sequence SEQ ID NO: - 13, optionally further comprising a methionine at the N-terminus, and a 40 kDa mPEG2 moiety covalently attached to Lys122; and
(b) a conjugate comprising a polypeptide comprising the sequence SEQ ID NO;
13, optionally further comprising a methionine at the N-terminus, and a 40 kDa mPEG2 moiety covalently attached to Lys135;
which composition exhibits antiviral activity. - View Dependent Claims (48)
- 13, optionally further comprising a methionine at the N-terminus, and a 40 kDa mPEG2 moiety covalently attached to Lys122; and
-
45. A composition comprising
(a) a conjugate comprising a polypeptide comprising the sequence SEQ ID NO: - 38, optionally further comprising a methionine at the N-terminus, and a 40 kDa mPEG2 moiety covalently attached to Lys31;
(b) a conjugate comprising a polypeptide comprising the sequence SEQ ID NO;
38, optionally further comprising a methionine at the N-terminus, and a 40 kDa mPEG2 moiety covalently attached to Lys122; and
(b) a conjugate comprising a polypeptide comprising the sequence SEQ ID NO;
38, optionally further comprising a methionine at the N-terminus, and a 40 kDa mPEG2 moiety covalently attached to Lys135;
which composition exhibits antiviral activity.
- 38, optionally further comprising a methionine at the N-terminus, and a 40 kDa mPEG2 moiety covalently attached to Lys31;
-
77. An isolated or recombinant polypeptide comprising the sequence SEQ ID NO:
- 39 or the sequence of a variant thereof wherein the variant differs in 1 to 3 amino acid positions from SEQ ID NO;
39, optionally further comprising a methionine at the N-terminus, which polypeptide exhibits antiviral activity.
- 39 or the sequence of a variant thereof wherein the variant differs in 1 to 3 amino acid positions from SEQ ID NO;
-
79. A conjugate comprising
(a) a polypeptide comprising the sequence SEQ ID NO: - 39 or the sequence of a variant thereof wherein the variant differs in 1 to 3 amino acid positions from SEQ ID NO;
39, optionally further comprising a methionine at the N-terminus; and
(b) a PEG moiety covalently attached to a lysine residue of the polypeptide, which conjugate exhibits antiviral activity.
- 39 or the sequence of a variant thereof wherein the variant differs in 1 to 3 amino acid positions from SEQ ID NO;
Specification