BIOELECTRO-OSMOTIC ENGINE FLUID DELIVERY DEVICE

• US 20070021734A1
• Filed: 07/12/2006
• Published: 01/25/2007
• Est. Priority Date: 07/15/2005
• Status: Abandoned Application

• Current Assignee: Microlin LLC
• Original Assignee: Microlin LLC
• Inventors: BHAVARAJU, SAI
• Application Number:
  US11/457,010
• Publication Number:
  US 20070021734A1
• Time in Patent Office: Days
• US Class Current: 604/891.100
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure

Abstract

Disclosed are embodiments of a fluid delivery device that may be used in implantable applications. In one illustrative embodiment, the fluid delivery device may include an electro-osmotic pump having a biocompatible electrode configured to oxidize body fluid.

Claims

1. A fluid delivery device, comprising:

a fluid reservoir configured to contain a fluid to be dispensed; and

an electrochemical pump configured to facilitate dispensing the fluid from the fluid reservoir, the electrochemical pump, comprising;

a driving chamber;

a first electrode comprising a cathode; and

a second electrode comprising an anode configured to oxidize a fuel present in a body of an animal;

wherein one of the electrodes is disposed within the driving chamber and one of the electrodes is disposed outside of the driving chamber.

2. The fluid delivery device of claim 1, wherein the electrochemical pump is an electro-osmotic pump and the driving chamber is capable of retaining water transported across an ion exchange membrane into the driving chamber to apply pressure to the fluid reservoir.

3. The fluid delivery device of claim 2, wherein the driving chamber displaces a displaceable member upon transportation of water across the ion exchange membrane, such that the displaceable member applies pressure to the fluid reservoir to dispense the fluid.

4. The fluid device of claim 2, wherein the ion exchange membrane is an anionic exchange membrane and the anode is disposed within the driving chamber.

5. The fluid delivery device of claim 2, wherein the ion exchange membrane is a cationic exchange membrane and the cathode is disposed within the driving chamber.

6. The fluid delivery device of claim 1, wherein the fluid comprises a beneficial agent.

7. The fluid device of claim 1, wherein the anode is an enzymatic anode.

8. The fluid delivery device of claim 7, wherein the enzymatic anode is biocompatible.

9. The fluid delivery device of claim 8, wherein the enzymatic anode uses direct electron transfer as an electron transfer mechanism such that the enzymatic anode is chosen from laccase, lactate dehydrogenase, peroxidase, and hydrogenase.

10. The fluid delivery device of claim 8, wherein the enzymatic anode uses mediator electron transfer as an electron transfer mechanism, such that the enzymatic anode is chosen from bilirubin oxidase and glucose oxidase.

11. The fluid delivery device of claim 8, wherein the enzymatic anode is configured to oxidize glucose.

12. The fluid delivery device of claim 8, wherein the enzymatic anode is configured to oxidize lactate.

13. The fluid delivery device of claim 1, wherein the cathode is chosen from a reducible metal chloride cathode and a metal oxide cathode.

14. The fluid delivery device of claim 1, wherein the cathode comprises an oxygen-reducing cathode.

15. The fluid delivery device of claim 14, wherein the cathode is chosen from silver, platinum and metal oxides deposited on a carbon substrate.

16. The fluid delivery device of claim 14, wherein the cathode is an enzymatic cathode which is chosen from bilirubin oxidase, laccase and cytochrome c oxidase.

17. The fluid delivery device of claim 14, wherein the cathode is porphyrin based.

18. The fluid delivery device of claim 1, further comprising a resistor coupled between the first electrode and the second electrode.

19. The fluid delivery device of claim 1, wherein the animal is a human.

20. An implantable device for dispensing a beneficial agent, comprising:

a fluid reservoir configured to contain the beneficial agent; and

an electrochemical pump configured to facilitate dispensing the beneficial agent from the fluid reservoir, the electrochemical pump comprising;

a first electrode comprising a metal chloride cathode; and

a second electrode comprising a glucose oxidation anode.

21. The device of claim 20, wherein the metal chloride cathode is a silver chloride cathode.

22. The device of claim 20, wherein the glucose oxidation anode is configured to be directly exposed to body fluid while the metal chloride cathode is disposed within a chamber separated from the glucose oxidation anode by a cationic exchange membrane.

23. The device of claim 20, wherein the metal chloride cathode is configured to be directly exposed to body fluid while the glucose oxidation anode is disposed within a chamber separated from the metal chloride cathode by an anionic exchange membrane.

24. The device of claim 20, wherein the electrochemical pump is an electro-osmotic pump capable of transporting water across an ion exchange membrane into a first driving chamber to apply pressure to the fluid reservoir.

25. A fluid delivery device, comprising:

means for housing a beneficial agent within the delivery device;

means for driving the beneficial agent from the housing means; and

means for applying pressure to the driving means, wherein the means for applying pressure comprises a first electrode comprising a cathode and a second electrode comprising and enzymatic anode, such that one of the electrodes is directly exposed to body fluid and one of the electrodes is separated from direct exposure to body fluid via an ion exchange membrane.

26. The fluid delivery device of claim 25, wherein the enzymatic anode is biocompatible and is configured to oxidize glucose.

27. The fluid delivery device of claim 26, wherein the cathode comprises a metal chloride.