DUAL MEMBRANE ELECTRO-OSMOTIC FLUID DELIVERY DEVICE

• US 20070021735A1
• Filed: 07/13/2006
• Published: 01/25/2007
• Est. Priority Date: 07/15/2005
• Status: Abandoned Application

• Current Assignee: Microlin LLC
• Original Assignee: Microlin LLC
• Inventors: Gordon, John, Bhavaraju, Sai
• Application Number:
  US11/457,373
• Publication Number:
  US 20070021735A1
• Time in Patent Office: Days
• US Class Current: 604/891.100
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: B01D 61/427 Electro-osmosis

Abstract

Disclosed are embodiments of a fluid delivery device that combine both anionic electrokinetic and cationic electrokinetic concepts. In one illustrative embodiment, the fluid delivery device may include an electro-osmotic pump having an anion exchange membrane and a cation exchange membrane in the same device.

Claims

1. A fluid delivery device, comprising:

a fluid reservoir configured to contain a fluid to be dispensed; and

an electrochemical pump capable of applying pressure to the fluid reservoir to dispense the fluid, the electrochemical pump, comprising;

a first electrode;

a second electrode;

an anion exchange membrane; and

a cation exchange membrane.

2. The fluid delivery device of claim 1, wherein the electrochemical pump is an electro-osmotic pump comprising a driving chamber capable of retaining water transported across at least one of the membranes into the driving chamber.

3. The fluid delivery device of claim 2, wherein the driving chamber displaces a displaceable member upon transportation of water across the at least one membrane, such that the displaceable member applies pressure to the fluid reservoir to dispense the fluid.

4. The fluid delivery device of claim 3, further comprising:

a second driving chamber and a second displaceable member, wherein the displaceable members comprise first and second pistons, such that first and second pistons simultaneously apply pressure to the fluid reservoir to dispense the fluid when water is transported into each driving chamber.

5. The fluid delivery device of claim 3, further comprising:

a second chamber, a second displaceable member and a second fluid reservoir, wherein the displaceable members comprise first and second fluid reservoir, wherein the displaceable members comprise first and second pistons, such that first and second pistons apply pressure to the fluid reservoirs to dispense the fluid when water is transported into each driving chamber.

6. The fluid delivery device of claim 5, wherein the fluid comprises a first fluid and a second fluid and each fluid reservoir contains a different fluid to be delivered.

7. The fluid delivery device of claim 1, wherein the fluid comprises a beneficial agent.

8. The fluid delivery device of claim 1, wherein the first electrode comprises an anode and a second electrode comprises a cathode, such that the cation exchange membrane is located adjacent the cathode and the anion exchange membrane is located adjacent the anode.

9. The fluid delivery device of claim 8, wherein the anode comprises a zinc anode and the cathode comprises a silver chloride cathode.

10. The fluid delivery device of claim 1, further comprising a resistor coupled between the first electrode and the second electrode.

11. An implantable device for dispensing a beneficial agent, comprising:

a first fluid reservoir having at least on e dispensing port, the first fluid reservoir configured to contain a first beneficial agent; and

an electrochemical pump to actuate the dispensing of the first beneficial agent from the first fluid reservoir, the electrochemical pump, comprising;

a first driving chamber comprising a first electrode and an anion exchange membrane; and

a second driving chamber comprising a second electrode and a cation exchange membrane.

12. The device of claim 11, wherein the anion exchange membrane and the cation exchange membrane are exposed to body fluid.

13. The device of claim 11, wherein the electromechanical pump is an electro-osmotic pump capable of transporting water across the anion exchange membrane and the cation exchange membrane into the first driving chamber and the second driving chamber, respectively.

14. The device of claim 11, wherein the at least one dispensing port is coupled to a catheter.

15. The device of claim 11, further comprising:

a second fluid reservoir having at least one dispensing port, the second fluid reservoir configured to contain a second beneficial agent,

wherein the first driving chamber is configured to apply pressure to the first fluid reservoir to dispense the first beneficial agent out of the at least one dispensing port of the first fluid reservoir and the second driving chamber is configured to apply pressure to the second fluid reservoir to dispense the second beneficial agent out of the at least one dispensing port of the second fluid reservoir.

16. The device of claim 15, wherein the first beneficial agent and the second beneficial agent are the same beneficial agent.

17. The device of claim 11, wherein the anion exchange membrane is configured to allow the transport of Cl⁻

across the anion exchange membrane and the cation exchange membrane is configured to allow the transport of Na⁺ across the cation exchange membrane.

18. The device of claim 17, wherein the transport of Cl⁻

and Na

across the anion and cation exchange membranes, respectively, further comprises the transport of a sheath of water molecules along with the transport of Cl⁻

and Na⁺ ions.

19. A fluid delivery device, comprising:

first means for driving a fluid from the delivery device;

second means for driving the fluid from the delivery device; and

means for applying pressure to the first and second driving means,

wherein the means for applying pressure comprises an anion exchange membrane and a cation exchange membrane.

20. The fluid delivery device of claim 19, further comprising a first means for housing the fluid, such that the first and second driving means drive the fluid out of the housing means upon receipt of pressure from the means for applying pressure.

21. The fluid delivery device of claim 19, further comprising a first means for housing the fluid, the fluid comprising a first fluid, and further comprising a second means for housing a second fluid, such that the first and second driving means drive the first and second fluids from the first and second housing means, respectively, upon receipt of pressure from the means for applying pressure.

22. The fluid delivery device of claim 21, wherein the first fluid is substantially identical to the second fluid.

23. The fluid delivery device of claim 19, wherein the means for applying pressure comprises an electrochemical pump having a first electrode and a second electrode, the first electrode being disposed in a first driving chamber adjacent the anion exchange membrane and the first driving means and the second electrode being disposed in the second driving chamber adjacent the cation exchange membrane and the second driving means.