Selective nerve stimulation for the treatment of angina pectoris

• US 20070021786A1
• Filed: 07/25/2005
• Published: 01/25/2007
• Est. Priority Date: 07/25/2005
• Status: Abandoned Application

• Current Assignee: LivaNova USA, Inc. (LivaNova Plc)
• Original Assignee: Cyberonics, Inc
• Inventors: Parnis, Steven M., Barrett, Burke T.
• Application Number:
  US11/188,971
• Publication Number:
  US 20070021786A1
• Time in Patent Office: Days
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

A method is disclosed for electrically stimulating a cranial nerve, especially a vagus nerve, to treat or alleviate angina pectoris. Pain is lessened or prevented by application of predetermined therapeutic electrical signal to a selected location on the cranial nerve of a patient using an implanted neurostimulating device. Such method employs selective application of electrical signals to a predetermined location on the nerve to alter the activity of the nerve and cause dilation of a coronary artery in the patient, which in turn provides complete or partial relief of chest pain or deters the onset of such pain.

Claims

1. A method of treating angina pectoris in a patient, the method comprising:

applying a therapeutic electrical signal to an electrode coupled to a cranial nerve of the patient at a selected site on the nerve, the signal being effective to dilate at least a portion of a coronary artery of the patient and thereby alleviate the angina without significantly slowing the heart rate ofthe patient.

14. The method of claim 1 wherein said step of coupling said electrode at said selected site on said nerve comprises positioning said electrode on the left vagus nerve in the neck area below the cardiac branch ofthe vagus nerve.

15. The method of claim 1 further comprising administering a pharmaceutical agent to said patient to further alleviate angina.

16. The method of claim 1 wherein said therapeutic electrical signal comprises an on-time and an off-time, and wherein said on-time comprises a time within the range of 1 second to 1 day, and said off-time comprises a time within the range of 0 seconds to 1 day.

2. The method of claim 2 wherein said electrode is coupled to a vagus nerve of the patient.

3. The method of claim 2 wherein said vagus nerve is a left vagus nerve of the patient.

4. The method of claim 2 comprising:

providing a pulse generator capable of generating a pulsed electrical signal;

providing at least one electrode;

implanting the pulse generator in the patient'"'"'s body;

surgically coupling said at least one electrode directly to a vagus nerve of the patient at a selected site on said nerve that is capable of causing dilation of at least a portion of a coronary artery of the patient when electrical stimulation is applied to said site;

coupling the pulse generator to the electrode;

generating a predetermined pulsed electrical signal by said pulse generator; and

applying said pulsed electrical signal to said at least one electrode such that at least a portion of said artery dilates and thereby at least partially relieves angina pectoris in said patient.

5. The method of claim 4 further comprising programming said electrical pulse generator to define said pulsed electrical signal by a plurality of predetermined parameters including a current magnitude, a pulse frequency, and a pulse width, wherein said predetermined parameters are capable of causing dilation of at least a portion of a coronary artery of the patient when said pulsed electrical signal is applied to said at least one electrode.

6. The method of claim 4 further comprising:

detecting at least one indicator of the onset of angina pectoris; and

applying of said electrical signal to said vagus nerve in response to the detection of said at least one indicator.

7. The method of claim 6 wherein said step of detecting comprises the patient subjectively experiencing chest pain, and said step of initiating comprises the patient taking action to start said application of said electrical signal.

8. The method of claim 6 further comprising:

obtaining an implantable sensor that is capable of sensing said indicator of the onset of angina pectoris;

implanting the sensor in the patient'"'"'s body at a predetermined sensing site; and

coupling the sensor to the programmed pulse generator, wherein said detecting comprises sensing said indicator of the onset of angina pectoris with said sensor.

9. The method of claim 8 wherein said at least one indicator of the onset of angina comprises decreased blood flow to the heart, and said sensor comprises a blood pressure sensor for measuring blood pressure.

10. The method of claim 6 wherein said at least one therapeutic electrical signal comprises:

a first therapeutic electrical signal for treating acute angina, wherein said first signal comprises a programmed first level of stimulation;

a second therapeutic electrical signal for treating chronic angina, wherein said second signal comprises a different level of stimulation than said first level of stimulation.

11. The method of claim 10 wherein said step of applying said at least one therapeutic signal comprises:

applying said second signal to said electrode; and

intermittently interrupting said application of said second signal with application of said first signal upon detecting said at least one indicator of the onset of angina pectoris.

12. The method of claim 11 wherein said step of intermittently interrupting application of said second signal with application of said first signal comprises sustaining application of said first signal until alleviation of angina is obtained or until said at least one indicator ceases to be detected.

13. The method of claim 12 wherein said patient suffers from chronic angina and said step of sustainedly applying said first therapeutic electrical signal is effective to dilate, or deter vasoconstriction of, at least a portion of a coronary artery of the patient and thereby deter or avoid onset of acute angina.

17. A method of selectively dilating a coronary artery in a patient in need thereof, the method comprising:

applying at least one therapeutic electrical signal to an electrode coupled to a cranial nerve of the patient at a selected site on said nerve effective to dilate at least a portion of the coronary artery and thereby increasing blood flow to the patient'"'"'s heart such that the increased arterial blood flow alleviates angina without significantly slowing the patients heart rate.

18. The method of claim 17 wherein said at least one therapeutic electrical signal is effective to deter the onset of an episode of acute angina.

19. The method of claim 17 comprising selecting a site on said nerve that has been determined to be a coronary artery-dilation effector site, wherein, when said effector site is stimulated at least a portion of a coronary artery is caused to be dilated inresponse to such stimulation.

20. The method of claim 17 wherein said cranial nerve is the vagus nerve of the patient and said selected site is an area on said nerve below the cardiac branches of the vagus nerve.

21. The method of claim 17 further comprising monitoring the heart rate of said patient, wherein said step of applying said at least one therapeutic electrical signal does not cause the patient'"'"'s heart rate to decrease more than about 20%.

22. The method of claim 21 wherein said step of applying said at least one therapeutic electrical signal does not cause the patients heart rate to decrease more than about 10%.

23. An implantable apparatus for deterring or preventing vasoconstriction or spasm of a coronary artery in a patient in need thereof the apparatus comprising:

an electrode coupled to a cranial nerve of the patient to stimulate said cranial nerve;

a power supply;

a pulse generator coupled to said power supply and to said electrode, wherein said pulse generator is adapted to apply a therapeutic electrical signal to said cranial nerve using said electrode, wherein said electrical signal is effective to modulate neuronal activity of said cranial nerve to counteract constriction of at least a portion of the artery without significantly slowing the patient'"'"'s heart rate.