Automatic baroreflex modulation responsive to adverse event

• US 20070021790A1
• Filed: 07/07/2006
• Published: 01/25/2007
• Est. Priority Date: 09/27/2000
• Status: Abandoned Application

• Current Assignee: CVRx, Inc.
• Original Assignee: CVRx, Inc.
• Inventors: Kieval, Robert, Serdar, David, Burns, Matthew
• Application Number:
  US11/482,358
• Publication Number:
  US 20070021790A1
• Time in Patent Office: Days
• US Class Current: 607/9
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

A system for providing baroreflex stimulation comprises a sensor to detect a parameter and provide a signal indicative of the parameter, and a baroreflex stimulator. The baroreflex stimulator includes a driver to provide a control signal adapted to deliver a baroreflex therapy, and a controller to receive the signal indicative of the parameter and modulate the control signal based on the signal indicative of the parameter to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.

Claims

1. A system for providing baroreflex stimulation, comprising:

an adverse event detector to sense an adverse event and provide a signal indicative of the adverse event; and

a baroreflex stimulator, including;

a pulse generator to provide a baroreflex stimulation signal adapted to provide a baroreflex therapy; and

a modulator to receive the signal indicative of the adverse event and modulate the baroreflex stimulation signal based on the signal indicative of the adverse event to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.

2. The system of claim 1, wherein the baroreflex signal has a characteristic selected from the set of:

an amplitude, a frequency, a burst frequency and a morphology, and the modulator includes a modulator to modulate the characteristic based on the signal indicative of the adverse event.

3. The system of claim 1, further comprising an implantable medical device, wherein the implantable medical device includes the adverse event detector and the baroreflex stimulator.

4. The system of claim 1, wherein the adverse event includes an adverse cardiac event.

5. The system of claim 4, wherein the adverse cardiac event is selected from the set of:

an arrhythmia and a non-arrhythmic cardiac event.

6. A baroreflex stimulator, comprising:

an implantable pulse generator to provide a baroreflex stimulation signal adapted to provide a baroreflex therapy; and

means for modulating the baroreflex stimulation signal based on a signal indicative of an adverse event to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.

7. The baroreflex stimulator of claim 6, wherein the means for modulating the baroreflex stimulation signal based on a signal indicative of an adverse event includes means for modulating the baroreflex stimulation signal based on a signal indicative of an event selected from the set of:

an adverse cardiac event, an arrhythmia and a non-arrhythmic cardiac event.

8. The baroreflex stimulator of claim 6, wherein the baroreflex stimulation signal has a characteristic selected from the set of:

an amplitude, a frequency, and a morphology, and the means for modulating the baroreflex stimulation signal includes means for adjusting the characteristic of the baroreflex stimulation signal.

9. A method for operating an implantable medical device, comprising:

receiving a signal regarding a detected adverse event at a baroreceptor stimulator

performing a first baropacing therapy using the baroreceptor stimulator when the adverse event is not detected; and

automatically performing a second baropacing therapy using the baroreceptor stimulator when the adverse event is detected.

10. The method of claim 9, wherein performing the first baropacing therapy includes withholding baropacing therapy and performing the second baropacing therapy includes providing baropacing stimulation.

11. The method of claim 9, wherein performing the first baropacing therapy includes providing baropacing stimulation and performing the second baropacing therapy includes withholding baropacing therapy.

12. The method of claim 9, wherein performing the second baropacing therapy includes identifying the adverse event, and applying a baropacing therapy for the adverse event.

13. The method of claim 9, further comprising:

detecting the adverse event using an adverse event detector in the implantable medical device; and

sending the signal regarding the adverse event to a baroreflex stimulator in the implantable medical device.

14. A system for providing baroreflex stimulation, comprising:

a sensor to detect a parameter and provide a signal indicative of the parameter; and

a baroreflex stimulator, including;

a driver to provide a control signal adapted to deliver a baroreflex therapy;

a controller to receive the signal indicative of the parameter and modulate the control signal based on the signal indicative of the parameter to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.

15. A baroreflex stimulator, comprising:

an implantable driver to provide a control signal adapted to provide a baroreflex therapy; and

a controller to receive the signal indicative of the parameter and modulate the control signal based on the signal indicative of the parameter to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.

16. A method for operating an implantable medical device, comprising:

receiving a signal indicative of a parameter at a baroreceptor stimulator;

performing a first baropacing therapy using the baroreceptor stimulator when the parameter is not detected; and

performing a second baropacing therapy using the baroreceptor stimulator when the parameter is detected.