Baroreflex stimulation synchronized to circadian rhythm

• US 20070021797A1
• Filed: 07/07/2006
• Published: 01/25/2007
• Est. Priority Date: 09/27/2000
• Status: Abandoned Application

• Current Assignee: CVRx, Inc.
• Original Assignee: CVRx, Inc.
• Inventors: Kieval, Robert, Rossing, Martin, Serdar, David, Burns, Matthew
• Application Number:
  US11/482,453
• Publication Number:
  US 20070021797A1
• Time in Patent Office: Days
• US Class Current: 607/44
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

A baroreflex stimulator is provided. The baroreflex stimulator includes a driver adapted to provide a control signal through a baroreceptor activation device, and a controller to periodically modulate the control signal based on an algorithm.

Claims

1. A baroreflex stimulator, comprising:

a pulse generator to provide a baroreflex stimulation signal through an electrode; and

a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm template.

2. The stimulator of claim 1, wherein the baroreflex signal has a characteristic selected from the set of:

an amplitude, a frequency and a desired morphology, and the modulator includes a modulator to modulate the characteristic based on the circadian rhythm template.

3. The stimulator of claim 1, wherein the circadian rhythm template includes a template selected from the set of a pre-programmed circadian rhythm template, a patient-specific circadian rhythm template, a mean arterial pressure template, a heart rate template, a stroke volume template, a cardiac output template, and a total peripheral resistance template.

4. The stimulator of claim 1, wherein the electrode includes an electrode adapted to stimulate baroreceptors in a vessel wall.

5. A baroreflex stimulator, comprising:

a pulse generator to provide a baroreflex stimulation signal through an electrode; and

means for modulating the baroreflex stimulation signal based on a circadian rhythm template.

6. The stimulator of claim 5, wherein the circadian rhythm template includes a template selected from the set of a pre-programmed circadian rhythm template, a patient-specific circadian rhythm template, a mean arterial pressure template, a heart rate template, a stroke volume template, a cardiac output template, and a total peripheral resistance template.

7. The stimulator of claim 5, wherein the baroreflex signal has a characteristic selected from the set of:

an amplitude, a frequency, a burst frequency and a waveform and the means for modulating the baroreflex stimulation signal based on a circadian rhythm template includes means for modulating the characteristic of the baroreflex stimulation signal based on a circadian rhythm template.

8. A method for operating an implantable medical device, comprising:

applying a baroreflex stimulation therapy using a baroreflex stimulator in the implantable medical device; and

modulating the baroreflex stimulation therapy based on a circadian rhythm template.

9. The method of claim 8, wherein modulating the baroreflex stimulation therapy includes modulating a characteristic of the baroreflex stimulation signal, wherein the characteristic is selected from the set of:

an amplitude, a frequency, a burst frequency, and a waveform.

10. The method of claim 8, wherein the modulating the baroreflex stimulation therapy uses a circadian rhythm template that is a pre-programmed circadian rhythm template.

11. The method of claim 8, further comprising:

sensing and recording parameters related to hypertension; and

generating a patient-specific circadian rhythm template based on the recorded parameters, wherein the baroreflex stimulation therapy is modulated based on the patient-specific circadian rhythm template.

12. The method of claim 8, wherein the modulating the baroreflex stimulation therapy uses a circadian rhythm template that includes a template selected from the set of:

a mean arterial pressure template, a heart rate template, a stroke volume template, a cardiac output template, and a total peripheral resistance template.

13. The method of claim 8, wherein applying baroreflex therapy includes stimulating a baroreceptor in a vessel wall.

14. A baroreflex stimulator, comprising:

a driver adapted to provide a control signal through a baroreceptor activation device; and

a controller to periodically modulate the control signal based on an algorithm.

15. A baroreflex stimulator, comprising:

a driver adapted to provide a control signal through a baroreceptor activation device; and

means for periodically modulating the control signal based on an algorithm.

16. A method for operating an implantable medical device, comprising:

applying a baroreflex stimulation therapy using a baroreceptor activation device in the implantable medical device; and

periodically modulating the baroreflex stimulation therapy based on an algorithm.