Baroreflex stimulation to treat acute myocardial infarction

• US 20070021798A1
• Filed: 07/07/2006
• Published: 01/25/2007
• Est. Priority Date: 09/27/2000
• Status: Abandoned Application

• Current Assignee: CVRx, Inc.
• Original Assignee: CVRx, Inc.
• Inventors: Kieval, Robert, Serdar, David, Burns, Matthew
• Application Number:
  US11/482,574
• Publication Number:
  US 20070021798A1
• Time in Patent Office: Days
• US Class Current: 607/44
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

An implantable medical system is provided. The implantable medical system includes a baroreflex stimulator to apply a baroreflex stimulation signal to an electrode, a sensor to detect a parameter indicative of heart failure, and a control system connected to the baroreflex stimulator and to the sensor. The control system is adapted to apply a baroreflex therapy in response to a detected parameter indicative of heart failure.

Claims

1. An implantable medical system, comprising:

a baroreflex stimulator to apply a baroreflex stimulation signal through an electrode;

a myocardial infarction detector to detect an event indicative of myocardial infarction; and

a controller connected to the baroreflex stimulator and to the myocardial infarction detector, the controller adapted to apply a baroreflex therapy in response to a detected event indicative of myocardial infarction.

2. The device of claim 1, wherein the event indicative of myocardial infarction includes a detected myocardial infarction.

3. The device of claim 1, wherein the controller includes a controller adapted to initiate a baroreflex therapy in response to a detected event indicative of myocardial infarction.

4. The device of claim 1, wherein the controller includes a controller adapted to increase an existing baroreflex therapy in response to a detected event indicative of myocardial infarction.

5. An implantable medical system, comprising:

means for detecting a myocardial infarction; and

means for applying baroreflex therapy to a pressoreceptive region to decrease coronary vascular resistance and increase blood flow in response to detecting the myocardial infarction.

6. The system of claim 5, wherein the means for applying baroreflex therapy includes means for increasing baroreflex stimulation in response to the myocardial infarction.

7. The system of claim 5, further comprising means for monitoring systemic blood pressure, and means for modulating the baroreflex therapy based on the systemic blood pressure.

8. The system of claim 5, further comprising means for sensing the blood pressure.

9. The system of claim 5, further comprising means for sensing respiration as a surrogate parameter for blood pressure.

10. A method, comprising:

detecting an event corresponding to a myocardial infarction; and

in response to a detected event corresponding to a myocardial infarction, applying a baroreflex therapy using an electrode positioned proximate to a baroreflex neural target.

11. The method of claim 10, further comprising monitoring systemic blood pressure and modulating the baroreflex therapy based on the blood pressure.

12. The method of claim 10, further comprising monitoring a surrogate parameter of systemic blood pressure and modulating the baroreflex therapy based on the surrogate parameter.

13. The method of claim 12, wherein the surrogate parameter includes a respiration parameter.

14. The method of claim 10, wherein the event corresponding to a myocardial infarction includes a detected myocardial infarction.

15. An implantable medical system, comprising:

a baroreflex stimulator to apply a baroreflex stimulation signal to an electrode;

a sensor to detect a parameter indicative of heart failure; and

a control system connected to the baroreflex stimulator and to the sensor, the control system adapted to apply a baroreflex therapy in response to a detected parameter indicative of heart failure.

16. An implantable medical system, comprising:

means for detecting a heart failure; and

means for applying baroreflex therapy to a baroreceptor region to regulate blood pressure and sympathetic nervous system activity.

17. A method, comprising:

detecting a parameter corresponding to heart failure; and

applying a baroreflex therapy using a baroreceptor activation device positioned adjacent a baroreceptor in response to detecting a parameter corresponding to heart failure.