Regional therapies for treatment of pain
First Claim
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1. A method for treating pain in a subject in need thereof, the method comprising:
- applying a first electrical signal having a frequency less than about 20 Hz to a first subcutaneous region in proximity to a source of pain of the subject;
applying a second electrical signal having a frequency greater than about 50 Hz to a second subcutaneous region in proximity to the source of pain of the subject, wherein the first and second subcutaneous regions are the same or different; and
administering a first pain treating agent to the subject at a predetermined time relative to application of the first or second electrical signal.
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Abstract
Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The therapies further include administering a pain treating agent at a predetermined time relative to application of the high or low frequency stimulation. Delivery of the pain treating agent via an implantable infusion system is described. Coordination of output of an infusion device and a pulse generator to provide coordinated therapy is also discussed.
54 Citations
39 Claims
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1. A method for treating pain in a subject in need thereof, the method comprising:
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applying a first electrical signal having a frequency less than about 20 Hz to a first subcutaneous region in proximity to a source of pain of the subject;
applying a second electrical signal having a frequency greater than about 50 Hz to a second subcutaneous region in proximity to the source of pain of the subject, wherein the first and second subcutaneous regions are the same or different; and
administering a first pain treating agent to the subject at a predetermined time relative to application of the first or second electrical signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A method for treating pain and reducing tolerance associated with the treatment, the method comprising:
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applying a first electrical signal having a frequency less than about 20 Hz to a first subcutaneous region in proximity to a source of pain of the subject;
applying a second electrical signal having a frequency greater than about 50 Hz to a second subcutaneous region in proximity to the source of pain of the subject, wherein the first and second subcutaneous regions are the same or different; and
administering a first pain treating agent to the subject, wherein the application of the first electrical signal, the second electrical signal, and the first pain treating agent occur in a cyclic manner. - View Dependent Claims (35, 36, 37, 38, 39)
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Specification