SMALL OBJECT MOVING ON PRINTED CIRCUIT BOARD

• US 20070023292A1
• Filed: 07/26/2006
• Published: 02/01/2007
• Est. Priority Date: 07/26/2005
• Status: Abandoned Application

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Kim, Chang-Jin, Gong, Jian
• Application Number:
  US11/460,188
• Publication Number:
  US 20070023292A1
• Time in Patent Office: Days
• US Class Current: 204/643
• CPC Class Codes: B01F 33/3031 using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: B01L 2300/089 Virtual walls for guiding liquids
• CPC Class Codes: B01L 2400/0421 electrophoretic flow
• CPC Class Codes: B01L 2400/0424 Dielectrophoretic forces
• CPC Class Codes: B01L 2400/0427 Electrowetting
• CPC Class Codes: B01L 3/502792 for moving individual droplets on a plate, e.g. by locally altering surface tension
• CPC Class Codes: F04B 19/006 Micropumps F04B43/043 and F04B43/095 take precedence

Abstract

A printed circuit board based digital or droplet microfluidic system and method for producing such microfluidic system are disclosed. The digital microfluidic device comprises a printed circuit board having a substrate and a plurality of electrode pads disposed on the top surface of the substrate in a rectangular array. A via extends from each electrode pad through the substrate to other locations on the substrate . A dielectric layer is disposed on the electrode pads. Droplets may be manipulated using electrowetting principles and others by applying a voltage to the desired electrodes. Each electrode pad can be controlled directly and independently from the other electrode pads to modify the surface wettability of the dielectric layer in the vicinity of the electrode pad by applying a voltage to the desired electrode pad(s). In this way, droplets may be formed, moved, mixed, and/or divided or other small objects manipulated while in air or immersed in a liquid on the dielectric surface.

Claims

1. A device for moving small objects comprising:

a substrate comprising a printed circuit board, the printed circuit board having a plurality of electrically isolated electrode pads disposed on an upper surface, the plurality of electrode pads operatively coupled to a plurality of electrical connections passing through the substrate, wherein each electrode pad is configured to be electrically activated independently of the other electrode pads;

a driving surface disposed over the plurality of electrode pads, the driving surface comprising a surface on which small objects may be placed and manipulated by the device; and

wherein each electrode pad is capable of moving one or more small moveable objects disposed on or above the driving surface in response to an electrical potential applied to at least one of the electrode pads.

2. The device of claim 1, wherein the small moveable object is selected from the group consisting of solid particles, liquid drops, gas bubbles, and their combinations, and the small moveable objects are immersed in a gas or a liquid.

3. The device of claim 1, further comprising a top plate placed over the printed circuit board with a space formed between the top plate and the printed circuit board such that the space forms a passage for the movable objects, a surface of the passage comprising the driving surface.

4. The device of claim 1, wherein the driving surface is selected from the group consisting of a dielectric layer disposed on the electrode pads, a low-friction layer disposed on the electrode pads, and a low friction layer overlaying a dielectric layer, the dielectric layer disposed on the electrode pads.

5. The device of claim 1, wherein the electrical connections comprise a plurality of vias extending from the electrode pads into the substrate to other surface locations of the substrate through intermediate conductive layers present in the substrate.

6. The device of claim 1, wherein a plurality of vias extends from the electrode pads through the substrate to a bottom surface of the substrate.

7. The device of claim 1, wherein the substrate layer is formed of one of FR4 or other materials used for printed circuit boards, and the electrode pads are formed of a copper layer or other materials used for printed circuit boards.

8. The device of claim 1, wherein the plurality of electrode pads is arranged in a predetermined pattern and the gap between the perimeters of adjacent electrode pads is between one (1) micrometer to one (1) millimeter.

9. The device of claim 4, wherein the electrode pads are formed of a conductive layer having a thickness of less than 100 micrometers, the dielectric layer has a thickness of less than 10 micrometers, and the low-friction layer has a thickness of less than 10 micrometers.

10. The device of claim 1, wherein the voltage required to move a small object on the driving surface is less than about 300 volts.

11. The device of claim 1, further comprising an interface device having a plurality of electrical connections electrically coupled to the contact electrodes, and a control board operatively coupled to the interface device, the control board configured to selectively apply voltages individually to each of the electrode pads to manipulate the small objects on the driving surface.

12. The device of claim 11, wherein the interface device is selected from the group consisting of insert-type connections, a ball grid array, pin grid array and a land grid array.

13. A method of producing an object moving system, comprising the following steps:

(a) providing a substrate comprising a printed circuit board;

(b) forming a plurality of electrically isolated electrode pads disposed on an upper surface of the printed circuit board;

(c) providing an electrical connection for each electrode pad, each electrical connection operatively coupled to its respective electrode pad and extending from the electrode pad into the substrate and electrically connecting to contact electrodes at other surface locations; and

(d) wherein the plurality of electrodes are capable of imparting a force on the movable objects in response to an electrical potential applied to at least one of the electrodes.

14. The method of claim 13, further comprising the step of providing a driving surface over the plurality of electrode pads, wherein the driving surface is selected from the group consisting of the electrode pads, a dielectric layer disposed on the electrode pads, a low-friction layer disposed on the electrode pads, and a low-friction layer overlaying a dielectric layer, the dielectric layer disposed on the electrode pads.

15. The method of claim 13, wherein, prior to step (b), a conductive layer on a top surface of the substrate is removed and a replacement conductive layer is provided on a top surface of the substrate, wherein the replacement conductive layer has a thinner and smoother surface topography than the removed conductive layer.

16. The method of claim 13, wherein, prior to step (b), a conductive layer on a top surface of the substrate is thinned down and/or smoothed by a lapping or polishing process.

17. The method of claim 14, further comprising the step of providing a top plate over the driving surface so as to form a passageway for the moveable objects.

18. The method of claim 13, wherein the printed circuit device is coupled with an interface device selected from the group consisting of insert-type connections, a ball grid array, pin grid array and a land grid array.

19. The method of claim 13, wherein the force is one of an electrowetting force, an electrophoretic force, a dielectrophoretic force, and an electrostatic force.

20. The method of claim 14, wherein the low-friction layer comprises a hydrophobic polymer.