METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR ANALYZING THREE DIMENSIONAL DATA SETS OBTAINED FROM A SAMPLE
First Claim
1. A method of analyzing three dimensional data sets obtained from a sample over time, comprising:
- obtaining a first three dimensional data set from the sample at a first time;
creating a first volume intensity projection (VIP) image from the first three dimensional data set;
identifying and registering at least one first landmark in the first VIP image;
obtaining a second three dimensional data set from the sample at a second time, different from the first time;
creating a second VIP image from the second three dimensional data set;
identifying and registering the at least one first landmark in the second VIP image; and
aligning the first and second VIP images based on the registered at least one first landmark in the first and second VIP images.
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Accused Products
Abstract
Methods of analyzing three dimensional data sets obtained from a sample over time are provided. A first three dimensional data set is obtained from the sample at a first time. A first volume intensity projection (VIP) image is created from the first three dimensional data set. One or more first landmarks are identified and registered in the first VIP image. A second three dimensional data set is obtained from the sample at a second time, different from the first time. A second VIP image is created from the second three dimensional data set. The one ore more first landmarks are identified and registered in the second VIP image. The first and second VIP images are aligned based on the registered one or more first landmarks in the first and second VIP images. Related systems and computer program products are also provided.
68 Citations
38 Claims
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1. A method of analyzing three dimensional data sets obtained from a sample over time, comprising:
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obtaining a first three dimensional data set from the sample at a first time;
creating a first volume intensity projection (VIP) image from the first three dimensional data set;
identifying and registering at least one first landmark in the first VIP image;
obtaining a second three dimensional data set from the sample at a second time, different from the first time;
creating a second VIP image from the second three dimensional data set;
identifying and registering the at least one first landmark in the second VIP image; and
aligning the first and second VIP images based on the registered at least one first landmark in the first and second VIP images. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for analyzing three dimensional data sets obtained from a sample, comprising:
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obtaining a first three dimensional data set from the sample at a first time;
creating a first volume intensity projection (VIP) image from the first three dimensional data set;
obtaining a second three dimensional data set from the sample at a second time, different from the first time;
rotating the second three dimensional data set to align an axis of the second three dimensional data set with an axis of the first three dimensional data set to obtain a rotated three dimensional data set; and
creating a rotated VIP image based on the rotated three dimensional data set. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A method of analyzing data sets obtained from a sample over time, comprising:
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identifying and registering at least one landmark in first and second volume intensity projection (VIP) images created from first and second three dimensional data sets, respectively; and
aligning the first and second VIP images based on the registered at least one first landmark to locate a common subject area in the first and second three dimensional data sets so as to allow comparison of the common subject area in the first and second three dimensional data sets at the first and the second times, respectively. - View Dependent Claims (15, 16)
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17. A system for analyzing three dimensional data sets obtained from a sample over time, comprising:
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a data set acquisition module configured to obtain a first three dimensional data set from the sample at a first time and a second three dimensional data set from the sample at a second time, different from the first time;
a volume intensity projection (VIP) module configured to create a first volume intensity projection (VIP) image from the first three dimensional data set and a second VIP image from the second three dimensional data set;
a registration module configured to identify and register at least one first landmark in the first VIP image and the at least one first landmark in the second VIP image; and
an alignment module configured to align the first and second VIP images based on the registered at least one first landmark in the first and second VIP images. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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24. A computer program product for analyzing three dimensional data sets obtained from a sample over time, the computer program product comprising:
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computer readable storage medium having computer readable program code embodied in said medium, the computer readable program code comprising;
computer readable program code configured to obtain a first three dimensional data set from the sample at a first time;
computer readable program code configured to create a first volume intensity projection (VIP) image from the first three dimensional data set;
computer readable program code configured to identify and register at least one first landmark in the first VIP image;
computer readable program code configured to obtain a second three dimensional data set from the sample at a second time, different from the first time;
computer readable program code configured to create a second VIP image from the second three dimensional data set;
computer readable program code configured to identify and register the at least one first landmark in the second VIP image; and
computer readable program code configured align the first and second VIP images based on the registered at least one first landmark in the first and second VIP images. - View Dependent Claims (25, 26, 27, 28, 29, 30)
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31. A method for analyzing three dimensional data sets obtained from a sample over time, comprising:
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obtaining a first three dimensional data set from the sample at a first time;
creating a first volume intensity projection (VIP) image from the first three dimensional data set;
identifying and registering at least one first landmark on the first VIP image;
registering a subject area in the first three dimensional data set on the first VIP image;
obtaining a second three dimensional data set at a second time, different from the first time;
creating a second VIP image from the second three dimensional data set;
identifying and registering the at least one first landmark on the second VIP image;
deriving alignment between the first at least one landmark registered on first VIP and second VIP images; and
locating the subject area registered in the first three dimensional data set in the second three dimensional data set based on registration of the at least one landmark derived from the first three dimensional data set and alignment between the first and second VIP images. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38)
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Specification