Reprogramming of adult or neonic stem cells and methods of use
First Claim
1. Reprogrammed stem cells obtained by exposing adult pluripotent stem or progenitor cells or pluripotent stem or progenitor cells obtained from placental or umbilical cord tissue or placental or umbilical cord blood or amniotic fluid or amnion exposed to a. an effective amount of embryonic stem cell medium or b. a denucleation procedure to remove nuclear DNA from said stem cell followed by introduction of nuclear material from a cell of a patient to be treated.
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Abstract
The present invention relates to methods of reprogramming adult stem cells or stem cells obtained from umbilical or placental cord blood or more preferably, the placeta or umbilical cord tissue itself or the amniotic fluid or amnion. The resulting stem cells and methods of using these stem cells represent additional aspects of the present invention. Stem cells according to the present invention, especially neonic stem cells (those obtained/reprogrammed from neonate stem cells), represent great potential in duplicating embryonic stem cell research without utilizing embryonic stems cells which have raised ethical and moral issues. The stem cells of the present invention which are reprogrammed are obtained from adults or from neonates without causing injury or death to a fetus in the case of embryonic stem cells and are non-controversial. In this sense, the present invention avoids many of the legal, ethical or moral considerations which have complicated the use of embryonic stem cells.
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Citations
27 Claims
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1. Reprogrammed stem cells obtained by exposing adult pluripotent stem or progenitor cells or pluripotent stem or progenitor cells obtained from placental or umbilical cord tissue or placental or umbilical cord blood or amniotic fluid or amnion exposed to
a. an effective amount of embryonic stem cell medium or b. a denucleation procedure to remove nuclear DNA from said stem cell followed by introduction of nuclear material from a cell of a patient to be treated.
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8. A method of reprogramming stem cells to produce non-controversial stem cells said method comprising:
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a. providing a sample comprising at least one stem cell obtained from an adult, from placental umbilical cord tissue or from umbilical cord or placental blood or from amniotic fluid or amnion tissue; and
b. exposing said sample to an effective amount of embryonic stem cell medium. - View Dependent Claims (9, 10, 11, 12, 13, 14, 17, 18)
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15. A method of reprogramming stem cells to produce non-controversial stem cells said method comprising:
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a. providing a sample comprising at least one stem cell obtained from an adult, from placental or umbilical cord tissue or from umbilical cord or placental blood, or from amniotic fluid or amnion tissue;
b. denucleating said stem cell from step a; and
c. introducing DNA from a patient into said denucleated stem cell. - View Dependent Claims (16, 19, 20)
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Specification