Devices and methods for enrichment and alteration of circulating tumor cells and other particles
First Claim
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1. A device for processing a cellular sample, said device comprising a channel comprising a structure that directs one or more first cells in a first direction to produce a first output sample enriched in said first cells and one or more second cells in a second direction to produce a second output sample enriched in said second cells, wherein said device is capable of processing at least 20 mL of fluid per hour.
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Abstract
The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.
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Citations
38 Claims
- 1. A device for processing a cellular sample, said device comprising a channel comprising a structure that directs one or more first cells in a first direction to produce a first output sample enriched in said first cells and one or more second cells in a second direction to produce a second output sample enriched in said second cells, wherein said device is capable of processing at least 20 mL of fluid per hour.
- 24. A system that is capable of being fluidically coupled to the circulatory system of a subject, said system comprising a device for processing a cellular sample, said device comprising a channel comprising a structure that directs one or more first cells in a first direction to produce a first output sample enriched in said first cells and one or more second cells in a second direction to produce a second output sample enriched in said second cells.
- 29. A method for depleting an analyte from a cellular sample, said method comprising introducing said cellular sample into a device for processing a cellular sample, said device comprising a channel comprising a structure that directs one or more first cells in a first direction to produce a first output sample enriched in said first cells and one or more second cells in a second direction to produce a second output sample enriched in said second cells, wherein said first output sample or said second output sample is depleted in said analyte relative to said cellular sample.
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33. A method for diagnosing a condition in a subject, said method comprising the steps of:
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a) introducing a cellular sample from said subject into a device for processing a cellular sample, said device comprising a channel comprising a structure that directs one or more first cells in a first direction to produce a first output sample enriched in said first cells and one or more second cells in a second direction to produce a second output sample enriched in said second cells, wherein said device is capable of processing at least 20 mL of fluid per hour;
b) analyzing said first output sample; and
c) diagnosing the presence or absence of said condition based on the results of step b). - View Dependent Claims (34, 35, 36, 37)
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Specification