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DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEMS

  • US 20070026519A1
  • Filed: 09/08/2006
  • Published: 02/01/2007
  • Est. Priority Date: 04/25/2001
  • Status: Abandoned Application
First Claim
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1. A pharmacokinetic-based microscale culture device, comprising:

  • a first microscale chamber dimensioned to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the first microscale chamber comprises a first inlet and a first outlet for flow of fluid;

    a second microscale chamber dimensioned to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to a value of at least one pharmacokinetic parameter obtained in vivo, wherein the second microscale chamber comprises a second inlet and a second outlet for flow of fluid;

    a microfluidic channel interconnecting the first and second microscale chambers wherein the microfluidic channel is dimensioned to transport the fluid; and

    a substance that is configured to adhere a portion of the biological material to a portion of the first or second microscale chambers or to a portion of the microfluidic channel.

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