High alcohol content gel-like and foaming compositions

• US 20070027055A1
• Filed: 08/22/2006
• Published: 02/01/2007
• Est. Priority Date: 09/29/2003
• Status: Active Grant

• Current Assignee: DEB IP Limited (SC Johnson & Son Incorporated)
• Original Assignee: DEB Worldwide Healthcare Incorporated
• Inventors: Fernandez de Castro, Maria, Koivisto, Bruce
• Granted Patent: US 7,683,018 B2
• Time in Patent Office: Days
• US Class Current: 510/383
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 25/16 Foams
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/08 acyclic, e.g. paraformaldehyde
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/661 Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/046 Aerosols; Foams
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/8123 Compositions of homopolymers or copolymers of compounds having one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers, e.g. PVC, PTFE
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61L 2/235 cellular, porous or foamed
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: C11D 1/004 : Surface-active compounds containing F
• CPC Class Codes: C11D 1/006 : Surface-active compounds containing fluorine and phosphorus
• CPC Class Codes: C11D 17/003 : Colloidal solutions, e.g. gels; Thixotropic solutions or pastes
• CPC Class Codes: C11D 17/0043 : For use with aerosol devices
• CPC Class Codes: C11D 3/0094 : High foaming compositions
• CPC Class Codes: C11D 3/201 : linear
• CPC Class Codes: C11D 3/2013 : fatty or with at least 8 carbon atoms in the alkyl chain

Abstract

This invention relates to a “high lower alcohol content” (>40% v/v of a C_1-4 alcohol) liquid composition able to be either dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers or as an alcohol gel composition which does not use thickener and gelling agents that leave undesirable deposits or a sticky after-feel and that has a final viscosity less than 4,000 cps. The liquid compositions comprise an alcohol, C_1-4 (>40% v/v), a fluorosurfactant of at least 0.001% by weight to prepare a foamable composition or from 0-2.0% to prepare a gel-like composition of a final viscosity less than 4,000 cps, 0-10% w/w of additional minor components added to obtain the desired performance (a foamable composition or a gel-like composition with a viscosity less than 4,000 cps), and the balance being purified water. The compositions may include emulsifier-emollients and mosturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.

Claims

1. A foamable alcohol composition, comprising;

a) an alcohol C_1-4, or mixtures thereof, present in an amount greater than about 40% v/v of the total composition;

b) an effective fluorinated surface active agent for foaming, which is physiologically acceptable for skin disinfecting, present in an amount of at least 0.001% by weight of the total composition such that the composition foams under low pressure conditions; and

c) water present in an amount to balance the total composition to 100% by weight.

2. The composition according to claim 1 wherein the effective physiologically acceptable fluorinated surface active agent is for wetting.

3. The composition according to claim 1 wherein the effective physiologically acceptable fluorinated surface active agent is a fluorosurfactant present in an amount from about 0.001% to about 10.0% by weight of the total composition.

4. The composition according to claim 1 wherein the effective physiologically acceptable fluorinated surface active agent is selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, and hydrocarbon surfactants.

5. The composition according to claim 1 wherein the alcohol C_1-4 is an aliphatic alcohol selected from the group consisting of methanol, ethanol, isopropanol, n-propanol, butanol and combinations thereof.

6. The composition according to claim 1 wherein the effective physiologically acceptable fluorinated surface active agent is an amphoteric polytetrafluoroethylene acetoxypropyl betaine (CF₃CF₂(CF₂CF₂)_nCH₂CH₂(OAc)CH₂N⁺(CH₃)₂CH₂COO⁻

) where n=2 to 4.

7. The composition according to claim 1 wherein the effective physiologically acceptable fluorinated surface active agent is an ethoxylated nonionic fluorosurfactant of the following structure:

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15, and y=1 to about 7.

8. The composition according to claim 1 wherein the effective physiologically acceptable fluorinated surface active agent is an anionic phosphate fluorosurfactant of the following structure:

(RfCH₂CH₂O)_xP(O₂)⁻

(NH₄)⁺_y, where Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7 or mixtures thereof.

9. The composition according to claim 1 wherein the effective physiologically acceptable fluorinated surface active agent is a mixture of two or more of the fluorosurfactants selected from the group consisting of amphoteric polytetrafluoroethylene acetoxypropyl betaine {(CF₃CF₂(CF₂CF₂)_nCH₂CH₂(OAc)CH₂N⁺(CH₃)₂CH₂COO⁻

) where n=2 to 4}, an ethoxylated nonionic fluorosurfactant of the following structure;

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15, and y=1 to about 7, and an anionic phosphate fluorosurfactant of the following structure;

(RfCH₂CH₂O)_xP(O)(ONH₄)_y where Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7 or mixtures thereof.

10. The composition according to claim 1 wherein the alcohol is present in a range from about 40% to about 90% v/v.

11. The composition according to claim 1 wherein the alcohol is ethanol present in an amount of at least 60% v/v, and wherein the composition is for use as an alcohol foam for skin disinfecting.

12. The composition according to claim 1 wherein the alcohol is a mixture of n-propanol and ethanol present in a combined amount of at least 60% v/v, and wherein the composition is for use as an alcohol foam for skin disinfecting.

13. The composition according to claim 1 wherein the alcohol is a mixture of isopropanol and ethanol present in a combined amount of at least 60% v/v, and wherein the composition is for use as an alcohol foam for skin disinfecting.

14. The composition according to claim 1 wherein the alcohol is isopropanol present in an amount of at least 70% v/v, and wherein the composition is for use as an alcohol foam for skin disinfecting.

15. The composition according to claim 1 wherein the alcohol is n-propanol present in an amount of at least 60% v/v, and wherein the composition is for use as an alcohol foam for skin disinfecting.

16. The composition according to claim 1 further including at least one additional surfactant for adjusting properties of the composition and/or the resulting foam produced from the composition.

17. The composition according to claim 16 wherein the additional surfactant is selected from the group consisting of a poly(ethoxylated and/or propoxylated)alcohol, a poly(ethoxylated and/or propoxylated)ester, a derivative of a poly(ethoxylated and/or propoxylated)alcohol, a derivative of a poly(ethoxylated and/or propoxylated)ester, an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a sorbitan fatty acid ester, a polyalkoxylated derivative of a sorbitan fatty acid ester, an alkylglucoside, a betaine, a sulfobetaine, an imidazoline derivative, an aminoacid derivative, a lecithin, a phosphatide, an amine oxide, a sulfoxide and mixtures thereof, present in an amount between about 0.10% to about 5% by weight.

18. The composition according to claim 17 wherein the betaine is cocamidopropyl betaine.

19. The composition according to claim 17 wherein the alkylglucoside is cocoglucoside.

20. The composition according to claim 17 wherein the polyethoxylated fatty alcohol is polyethoxylated stearyl alcohol (2 moles ethylene oxide).

21. The composition according to claim 17 wherein the polyethoxylated fatty alcohol is polyethoxylated stearyl alcohol (2 moles ethylene oxide).

22. The composition according to claim 17 wherein the polyethoxylated fatty alcohol is a combination of polyethoxylated stearyl alcohol (21 moles ethylene oxide) and polyethoxylated stearyl alcohol (2 moles ethylene oxide).

23. The composition according to claim 1 including a foam stabilizing agent present in an amount up to 5% by weight.

24. The composition according to claim 23 wherein the foam stabilizing agent is selected from the group consisting of lactic acid esters of monoglycerides, cationic emulsifiers, triquaternized stearic phospholipid complex, hydroxystearamide propyltriamine salts, lactic acid monoglycerides, food emulsifiers selected from the group consisting of glyceryl monostearate, propylene glycol monostearate, sodium stearoyl lactylate, cetyl betaine, glycolether, n-propanol, butyleneglycol, silicone wax, an encapsulated oil, Microcapsule Mineral Oil®

, and combinations thereof.

25. The composition according to claim 23 wherein the foam stabilizing agent is selected from the group consisting of glycolether, n-propanol, butyleneglycol, and combinations thereof.

26. The composition according to claim 1 including any one of a moisturizer, emollient and combinations thereof selected from the group consisting of lanolin, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from the group consisting of glycerol, propylene glycol, butyleneglycol and sorbitol and a fatty alcohol selected from the group consisting of cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol and palmityl alcohol, cetyl alcohol, ceteareth 20, an alkylglucoside and combinations thereof, present in an amount up to 5% by weight.

27. The composition according to claim 1 further comprising an acid or a base to adjust a pH of the composition to a pre-selected pH present in an amount from about 0.05 to about 0.5% by weight of the total composition.

28. The composition according to claim 27 wherein when an acid is used to adjust the pH the acid is selected from the group consisting of hydrochloric acid, citric acid and phosphoric acid, and wherein when a base is used to adjust the pH the base is sodium sesquicarbonate.

29. The composition according to claim 1 including a preservative in an amount from about 0.01 to about 5% by weight of the total composition.

30. The composition according to claim 1 including an antimicrobial agent.

31. The composition according to claim 30 wherein the antimicrobial agent is chlorhexidine gluconate present in an amount between about 0.50% to about 4.0% by weight.

32. The composition according to claim 30 wherein the antimicrobial agent is didecyl dimethyl ammonium chloride present in an amount between about 0.05% to about 5.0% by weight.

33. The composition according to claim 30 wherein the antimicrobial agent is selected from the group of a chlorhexidine salt, iodine, a complexed form of iodine, parachlorometaxylenol, triclosan, hexachlorophene, a phenol, a surfactant having a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a silver salt, silver oxide, and mixtures thereof.

34. The composition according to claim 1 further comprising constituents selected from the group consisting of organic gums and colloids, lower alkanolamides of higher fatty acids, short chain diols and/or triols, fragrance, coloring matter, ultraviolet absorbers, solvents, suspending agents, buffers, conditioning agents, antioxidants, bactericides and medicinally active ingredients, and combinations thereof.

35. The composition according to claim 1 stored in an unpressurized dispenser having a dispenser pump for mixing the composition with air and dispensing foam therefrom.

55. The foamable alcohol composition according to claim 1, wherein the alcohol C_1-4 or mixtures thereof is ethanol present in an amount between about 60% to 70% v/v of the total composition, and the effective physiologically acceptable fluorinated surface active agent is present in an amount from about 0.01% to about 2.0% by weight of the total composition.

56. The foamable alcohol composition according to claim 55 wherein the fluorosurfactant is an amphoteric polytetrafluoroethylene acetoxypropyl betaine (CF₃CF₂(CF₂CF₂)nCH₂CH₂(OAc)CH₂N⁺(CH₃)₂CH₂COO⁻

) where n=2 to 4.

57. The foamable alcohol composition according to claim 55 wherein the fluorosurfactant is an ethoxylated nonionic fluorosurfactant of the following structure:

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15 and y=1 to about 7.

58. The foamable alcohol composition according to claim 55 wherein the fluorosurfactant is an anionic phosphate fluorosurfactant of the following structure:

(RfCH₂CH₂O)_xP(O₂)⁻

(NH₄)⁺_y, where Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7.

59. The foamable alcohol composition according to claim 55 wherein the fluorosurfactant is selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, hydrocarbon surfactants, and a mixture of two or more of the fluorosurfactants selected from the group consisting of amphoteric polytetrafluoroethylene acetoxypropyl betaine {(CF₃CF₂(CF₂CF₂)nCH₂CH₂(OAc)CH₂N+(CH₃)₂CH₂COO—

) where n=2 to 4}, an ethoxylated nonionic fluorosurfactant of the following structure;

RfCH₂CH₂O(CH₂CH₂O)xH where Rf=F(CF₂CF₂)y, x=0 to about 15, and y=1 to about 7, and an anionic phosphate fluorosurfactant of the following structure;

(RfCH₂CH₂O)xP(O)(ONH₄)y where Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7 or mixtures thereof.

60. The foamable alcohol composition according to claim 55 further comprising at least one secondary surfactant present in an amount from about 0.01 to about 10.0% by weight of the total composition, wherein the secondary surfactant is at least one selected from the group consisting of a poly(ethoxylated and/or propoxylated)alcohol, a poly(ethoxylated and/or propoxylated)ester, a derivative of a poly(ethoxylated and/or propoxylated)alcohol, a derivative of a poly(ethoxylated and/or propoxylated)ester, an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a sorbitan fatty acid ester, a polyalkoxylated derivative of a sorbitan fatty acid ester, a betaine, a sulfobetaine, an imidazoline derivative, an aminoacid derivative, a lecithin, a phosphatide, an amine oxide, a sulfoxide and mixtures thereof, present in an amount between about 0.10% to about 5% by weight.

61. The foamable alcohol composition according to claim 60 wherein the secondary surfactant is cocoamidopropyl betaine.

62. The foamable alcohol composition according to claim 55 including an emulsifier or mixture of emulsifiers present in an amount between about 0.10% to about 1.5% by weight.

63. The foamable alcohol composition according to claim 62 wherein the emulsifier is a mixture of cetyl ethers and stearyl ethers of polyethylene oxide having an average of about 20 oxide units.

64. The foamable alcohol composition according to claim 55 further comprising a foam stabilizing agent, wherein the foam stabilizing agent is cetyl betaine.

65. The foamable alcohol composition according to claim 55 including an antimicrobial agent.

66. The foamable alcohol composition according to claim 65 wherein the antimicrobial agent is chlorhexidine gluconate present in an amount between about 0.50% to about 4.0% by weight.

67. The foamable alcohol composition according to claim 65 wherein the antimicrobial agent is didecyl dimethyl ammonium chloride present in an amount between about 0.50% to about 5.0% by weight.

68. The foamable alcohol composition according to claim 65 wherein the antimicrobial agent is selected from the group of a chlorhexidine salt, iodine, a complexed form of iodine, parachlorometaxylenol, triclosan, hexachlorophene, a phenol, a surfactant having a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a silver salt, silver oxide, and mixtures thereof.

69. The foamable alcohol composition according to claims 55 including a preservative in an amount from about 0.01 to about 5% by weight of the total composition.

70. The foamable alcohol composition according to claim 55 further comprising an acid or a base to adjust a pH of the disinfecting composition to a pre-selected pH present in an amount from about 0.05 to about 0.5% by weight of the total composition.

71. The foamable alcohol composition according to claim 70 wherein the acid is selected from the group consisting of hydrochloric acid, citric acid and phosphoric acid, and the base is sodium sesquicarbonate.

72. The foamable alcohol composition according to claim 55 stored in an unpressurized dispenser having a dispenser pump for mixing the disinfecting composition with air and dispensing foam therefrom.

73. The foamable alcohol composition according to claim 55 stored in a pressurized dispenser having a dispenser pump for mixing the disinfecting composition with air or a propellant and dispensing foam therefrom, the disinfecting composition including an aerosol propellant in an amount from about 3 to about 20% by weight of the total composition.

74. The foamable alcohol composition according to claim 73 wherein the aerosol propellant is selected from the group consisting of propane, carbon dioxide, butane, dichloro difluoro methane, dichloro tetra fluoro ethane octafluorocyclo butane;

1,1,1,2-tetrafluoroethane;

1,1,1,2,3,3,3 heptafluoropropane, and 1,1,1,3,3,3,-hexafluoropropane.

75. The foamable alcohol composition according to claim 73 including a corrosion inhibitor is selected from the group consisting of sorbic acid, benzoic acid, potassium sorbate and sodium benzoate, in an amount from about 0.1 to about 5% by weight of the total composition.

76. The foamable alcohol composition according to claim 55 including a moisturizer and/or emollient selected from the group consisting of lanolin, alkylglucoside, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from the group consisting of glycerol, propylene glycol, glyceryl oleate and sorbitol, or a fatty alcohol selected from the group consisting of cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol and palmityl alcohol, cetyl alcohol, ceteareth 20, and combinations thereof, present in an amount up to 5% by weight.

77. The foamable alcohol composition according to claim 55 further comprising other constituents or materials including organic gums and colloids, lower alkanolamides of higher fatty acids, short chain diols and/or triols, fragrance, coloring matter, additional emollients, ultraviolet absorbers, solvents, emulsifiers, foam stabilizers or mixture of such stabilizers, suspending agents, buffers, conditioning agents, antioxidants, bactericides, medicinal active ingredient, and the like) that may be commonly added to aerosol compositions, toiletries, cosmetics and pharmaceuticals.

105. The foamable alcohol composition according to claim 1 wherein said effective fluorinated surface active agent is an anionic phosphate fluorosurfactant.

36. A foamable alcohol disinfecting composition, comprising:

a) an alcohol C_1-4, or mixtures thereof, present in an amount between about 60% to about 80% v/v of the total composition;

b) a physiologically acceptable fluorosurfactant present in an amount from about 0.01% to about 2.0% by weight of the total composition such that the foamable alcohol disinfecting composition foams under low pressure conditions when dispensed from an unpressurized container;

c) a foam stabilizing agent present in an amount from about 0.01 to about 12.0% by weight;

d) any one of moisturizers, emollients and combinations thereof present in an amount from about 0.05 to about 5.0% by weight; and

e) water in an amount to balance the total composition to 100% by weight.

37. The foamable alcohol disinfecting composition according to claim 36 wherein the physiologically acceptable fluorosurfactant is for wetting.

38. The foamable alcohol disinfecting composition according to claim 36 wherein the physiologically acceptable fluorosurfactant is an amphoteric polytetrafluoroethylene acetoxypropyl betaine (CF₃CF₂(CF₂CF₂)nCH₂CH₂(OAc)CH₂N+(CH3)₂CH₂COO—

) where n=2 to 4.

39. The foamable alcohol disinfecting composition according to claim 36 wherein the physiologically acceptable fluorosurfactant is an ethoxylated nonionic fluorosurfactant of the following structure:

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15 and y=1 to about 7.

40. The foamable alcohol disinfecting composition according to claim 36 wherein the physiologically acceptable fluorosurfactant is an anionic phosphate fluorosurfactant of the following structure:

(RfCH₂CH₂O)_xP(O₂)⁻

(NH₄)⁺_y, where

Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7.

41. The foamable alcohol disinfecting composition according to claim 36 wherein the physiologically acceptable fluorosurfactant is selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, hydrocarbon surfactants, and a mixture of two or more of the fluorosurfactants selected from the group consisting of amphoteric polytetrafluoroethylene acetoxypropyl betaine {(CF₃CF₂(CF₂CF₂)_nCH₂CH₂(OAc)CH₂N⁺(CH₃)₂CH₂COO⁻

) where n=2 to 4}, an ethoxylated nonionic fluorosurfactant of the following structure;

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15, and y=1 to about 7, and an anionic phosphate fluorosurfactant of the following structure;

(RfCH₂CH₂O)_xP(O)(ONH₄)_y where Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7 or mixtures thereof.

42. The foamable alcohol disinfecting composition according to claim 36 wherein the foam stabilizing agent is selected from the group consisting of lactic acid esters of monoglycerides, cationic emulsifiers, triquaternized stearic phospholipid complex, hydroxystearamide propyltriamine salts, lactic acid monoglycerides, food emulsifiers selected from the group consisting of glyceryl monostearate, propylene glycol monostearate and sodium stearoyl lactylate, silicone wax, an encapsulated oil, Microcapsule Mineral Oil®

, butyleneglycol, butoxyethanol and n-propanol and mixtures thereof.

43. The foamable alcohol disinfecting composition according to claim 36 wherein the foam stabilizing agent is selected from the group consisting of butoxyethanol, glycolether, n-propanol, butyleneglycol, and combinations thereof.

44. The foamable alcohol disinfecting composition according to claim 36 wherein said any one of a moisturizer, emollient and combinations thereof are selected from the group consisting of lanolin, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from the group consisting of glycerol, propylene glycol, butyleneglycol and sorbitol and a fatty alcohol selected from the group consisting of cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol and palmityl alcohol, cetyl alcohol, ceteareth 20, an alkylglucoside and combinations thereof, present in an amount up to 5% by weight.

45. The foamable alcohol disinfecting composition according to claim 36 including a moisturizer and an emollient selected from the group consisting of glyceryl oleate, glycerine, cocoglucoside and combinations thereof.

46. The foamable alcohol disinfecting composition according to claim 36 including an antimicrobial agent.

47. The foamable alcohol disinfecting composition according to claim 46 wherein the antimicrobial agent is chlorhexidine gluconate present in an amount between about 0.50% to about 4.0% by weight.

48. The foamable alcohol disinfecting composition according to claim 46 wherein the antimicrobial agent is didecyl dimethyl ammonium chloride present in an amount between about 0.50% to about 5.0% by weight.

49. The foamable alcohol disinfecting composition according to claim 46 wherein the antimicrobial agent is selected from the group of a chlorhexidine salt, iodine, a complexed form of iodine, parachlorometaxylenol, triclosan, hexachlorophene, a phenol, a surfactant having a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a silver salt, silver oxide, and mixtures thereof.

50. The foamable alcohol disinfecting composition according to claim 36 including a preservative in an amount from about 0.01 to about 5% by weight of the total composition.

51. The foamable alcohol disinfecting composition according to claim 36 further comprising an acid or a base to adjust a pH of the disinfecting composition to a pre-selected pH present in an amount from about 0.05 to about 0.5% by weight of the total composition.

52. The foamable alcohol disinfecting composition according to claim 51 wherein the acid is selected from the group consisting of hydrochloric acid, citric acid and phosphoric acid, and the base is sodium sesquicarbonate.

53. The foamable alcohol disinfecting composition according to claim 36 stored in an unpressurized dispenser having a dispenser pump for mixing the disinfecting composition with air and dispensing foam therefrom.

54. The foamable alcohol disinfecting composition according to claim 36 further comprising other constituents or materials including organic gums and colloids, lower alkanolamides of higher fatty acids, short chain diols and/or triols, fragrance, coloring matter, additional emollients, ultraviolet absorbers, solvents, emulsifiers, foam stabilizers or mixture of such stabilizers, suspending agents, buffers, conditioning agents, antioxidants, bactericides, medicinal active ingredients for aerosol compositions, toiletries, cosmetics and pharmaceuticals.

78. A method of forming a skin disinfecting foam containing alcohol, comprising the steps of:

combining an alcohol C_1-4, or mixtures thereof, present in an amount greater than about 60% v/v of the total composition with a physiologically acceptable effective fluorinated surface active agent for foaming present in an amount of at least 0.001% by weight percent of the total composition, and water present in an amount to balance the total composition to 100% by weight to form an alcohol-fluorosurfactant mixture and storing said composition in an unpresssurized dispenser having a dispenser pump; and

activating the dispenser pump to combine the alcohol-fluorosurfactant mixture with air to form and dispense a skin disinfecting foam containing alcohol.

79. The method of claim 78 wherein the effective physiologically acceptable fluorinated surface active agent is for wetting.

80. The method according to claim 78 wherein the effective physiologically acceptable fluorinated surface active agent is a fluorosurfactant present in an amount from about 0.001% to about 10.0% by weight of the total composition.

81. The method according to claim 78 wherein the effective physiologically acceptable fluorinated surface active agent is selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, and hydrocarbon surfactants.

82. The method according to claim 78 wherein the alcohol C_1-4 is an aliphatic alcohol selected from the group consisting of methanol, ethanol, isopropanol, n-propanol, butanol and combinations thereof.

83. The method according to claim 80 wherein the fluorosurfactant is an amphoteric polytetrafluoroethylene acetoxypropyl betaine (CF₃CF₂(CF₂CF₂)_nCH₂CH₂(OAc)CH₂N⁺(CH₃)₂CH₂COO⁻

) where n=2 to 4.

84. The method according to claim 80 wherein the fluorosurfactant is an ethoxylated nonionic fluorosurfactant of the following structure:

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15, and y=1 to about 7.

85. The method according to claim 80 wherein the fluorosurfactant is an anionic phosphate fluorosurfactant of the following structure:

(RfCH₂CH₂O)_xP(O₂)⁻

(NH₄)⁺_y, where Rf=F(CF₂CF₂)_z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7 or mixtures thereof.

86. The method according to claim 80 wherein the fluorosurfactant is a mixture of two or more of the fluorosurfactants selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, hydrocarbon surfactantsin, amphoteric polytetrafluoroethylene acetoxypropyl betaine (CF₃CF₂(CF₂CF₂)_nCH₂CH₂(OAc)CH₂N⁺(CH₃)₂CH₂COO⁻

) where n=2 to 4, ethoxylated nonionic fluorosurfactant of the following structure;

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15, and y=1 to about 7, and anionic phosphate fluorosurfactant of the following structure;

(RfCH₂CH₂O)_xP(O)(ONH₄)_y where Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7.

87. The method according to claim 78 wherein the alcohol is present in a range from about 60% to about 90% v/v.

88. The method according to claim 78 further including at least one additional surfactant for adjusting properties of the foam produced from the composition.

89. The method according to claim 88 wherein the additional surfactant is selected from the group consisting of a poly(ethoxylated and/or propoxylated)alcohol, a poly(ethoxylated and/or propoxylated)ester, a derivative of a poly(ethoxylated and/or propoxylated)alcohol, a derivative of a poly(ethoxylated and/or propoxylated)ester, an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a sorbitan fatty acid ester, a polyalkoxylated derivative of a sorbitan fatty acid ester, an alkylglucoside, a betaine, a sulfobetaine, an imidazoline derivative, an aminoacid derivative, a lecithin, a phosphatide, an amine oxide, a sulfoxide and mixtures thereof, present in an amount between about 0.10% to about 5% by weight.

90. A high-alcohol, foamable, skin-disinfecting composition, comprising:

a) an alcohol C_1-4, or mixtures thereof, present in an amount greater than about 60% v/v of the total composition;

b) water present in an amount to balance the total composition to 100% by weight; and

c) a physiologically acceptable fluorinated surface active agent for foaming present in an amount of at least 0.001% by weight of the total composition such that the composition has a surface tension less than 20 dynes/cm.

91. The composition of claim 90 wherein the effective physiologically acceptable fluorinated surface active agent is for wetting.

92. The composition according to claim 90 wherein the effective physiologically acceptable fluorinated surface active agent is a fluorosurfactant present in an amount from about 0.001% to about 10.0% by weight of the total composition.

93. The composition according to claim 90 wherein the effective physiologically acceptable fluorinated surface active agent is selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, and hydrocarbon surfactants.

94. The composition according to claim 90 wherein the alcohol C_1-4 is an aliphatic alcohol selected from the group consisting of methanol, ethanol, isopropanol, n-propanol, butanol and combinations thereof.

95. The composition according to claim 92 wherein the fluorosurfactant is an amphoteric polytetrafluoroethylene acetoxypropyl betaine (CF₃CF₂(CF₂CF₂)_nCH₂CH₂(OAc)CH₂N⁺(CH₃)₂CH₂COO⁻

) where n=2 to 4.

96. The method according to claim 92 wherein the fluorosurfactant is an ethoxylated nonionic fluorosurfactant of the following structure:

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15, and y=1 to about 7.

97. The composition according to claim 92 wherein the fluorosurfactant is an anionic phosphate fluorosurfactant of the following structure:

(RfCH₂CH₂O)_xP(O₂)⁻

(NH₄)⁺_y, where Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7 or mixtures thereof.

98. The composition according to claim 92 wherein the fluorosurfactant is a mixture of two or more of the fluorosurfactants selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, hydrocarbon surfactantsin, amphoteric polytetrafluoroethylene acetoxypropyl betaine (CF₃CF₂(CF₂CF₂)_nCH₂CH₂(OAc)CH₂N⁺(CH₃)₂CH₂COO⁻

) where n=2 to 4, ethoxylated nonionic fluorosurfactant of the following structure;

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15, and y=1 to about 7, and anionic phosphate fluorosurfactant of the following structure;

(RfCH₂CH₂O)_xP(O₂)⁻

(NH₄)⁺_y, where Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7.

99. The composition according to claim 90 wherein the alcohol is present in a range from about 60% to about 90% v/v.

100. The composition according to claim 90 further including at least one additional surfactant for adjusting properties of the foam produced from the composition.

101. The composition according to claim 100 wherein the additional surfactant is selected from the group consisting of a poly(ethoxylated and/or propoxylated)alcohol, a poly(ethoxylated and/or propoxylated)ester, a derivative of a poly(ethoxylated and/or propoxylated)alcohol, a derivative of a poly(ethoxylated and/or propoxylated)ester, an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a sorbitan fatty acid ester, a polyalkoxylated derivative of a sorbitan fatty acid ester, an alkylglucoside, a betaine, a sulfobetaine, an imidazoline derivative, an aminoacid derivative, a lecithin, a phosphatide, an amine oxide, a sulfoxide and mixtures thereof, present in an amount between about 0.10% to about 5% by weight.

102. A high-alcohol, foamable, skin-disinfecting composition, comprising:

a) an alcohol C_1-4, or mixtures thereof, present in an amount greater than about 60% v/v of the total composition;

b) water present in an amount to balance the total composition to 100% by weight; and

c) a physiologically acceptable fluorinated surface active agent for foaming present in an amount of at least 0.001% by weight of the total composition such that the composition foams without the use of propellants or pressurized containers.

103. A method for personal disinfecting comprising:

applying to a person'"'"'s skin a skin-disinfecting alcohol foam composition which comprises

a) air mixed under low pressure conditions with

b) a liquid comprising

i) an alcohol C_1-4, or mixtures thereof, present in an amount greater than about 60% v/v of the total composition;

ii) water present in an amount to balance the total composition to 100% by weight; and

iii) a physiologically acceptable effective fluorinated surface active agent for foaming present in an amount of at least 0.001% by weight of the total composition.

104. A method for producing, and applying to a person'"'"'s skin, a skin-disinfecting alcohol foam composition, comprising

a) combining an alcohol C_1-4, or mixtures thereof, present in an amount greater than about 60% v/v of the total composition with an effective physiologically acceptable fluorinated surface active agent for foaming present in an amount of at least 0.001% by weight of the total composition, and water present in an amount to balance the total composition to 100% by weight to form an alcohol-fluorosurfactant mixture and storing said composition in an unpressurized dispenser having a dispenser pump;

b) activating the dispenser pump to combine the alcohol-fluorosurfactant mixture with air to form and dispense a skin-disinfecting alcohol foam; and

c) applying the skin-disinfecting alcohol foam to the person'"'"'s skin.

106. A foamable alcohol skin disinfecting composition, comprising;

a) ethanol present in an amount between about 60% to 70% v/v of the total composition;

b) a physiologically acceptable anionic phosphate fluorosurfactant for foaming present in an amount from about 0.001% to about 5.0% by weight of the total composition; and

c) water in an amount to balance the total composition to 100% by weight.

107. The foamable alcohol skin disinfecting composition according to claim 106 including a foam stabilizing agent.

108. The foamable alcohol skin disinfecting composition according to claim 107 wherein said foam stabilizing agent is selected from the group consisting of 1,3-Butyleneglycol, Butoxyethanol and combinations thereof.

109. The foamable alcohol skin disinfecting composition according to claim 108 wherein said foam stabilizing agent is present in a range from about 0.001 to about 3% by weight.

110. The foamable alcohol skin disinfecting composition according to claim 106 including a lipid layer enhancer.

111. The foamable alcohol skin disinfecting composition according to claim 110 wherein said lipid layer enhancer is selected from the group consisting of alkylglucoside, glyceryl oleate and combinations thereof.

112. The foamable alcohol skin disinfecting composition according to claim 106 including n-propanol present in an amount of at least about 1% v/v.

113. The foamable alcohol skin disinfecting composition according to claim 106 wherein said physiologically acceptable anionic phosphate fluorosurfactant for foaming present in an amount from about 0.001% to about 2.0% by weight.