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Novel compounds of amino sulfonyl derivatives

  • US 20070027118A1
  • Filed: 04/06/2006
  • Published: 02/01/2007
  • Est. Priority Date: 04/07/2005
  • Status: Abandoned Application
First Claim
Patent Images

1. A compound of formula (I):

  • embedded image wherein;

    R1 is 2-pyridinyl which is fused or substituted with 1-3 R6′

    groups, with at least one R6 group being at the 6′

    position of the pyridinyl;

    b is 2;

    R2 and R3 are taken together with the nitrogen atom to which they are attached to form a (4 to

         11)-membered heterocyclyl, and the (4 to

         11)-membered heterocyclyl may optionally be substituted by 1 to 3 R6 groups;

    the carbon atoms of R1, R2, and R3 may each be optionally substituted by 1 to 3 R6 groups;

    each R6 group is independently selected from the group consisting of halo, cyano, nitro, —

    CF3, —

    CHF2, —

    CH2F, trifluoromethoxy, azido, hydroxy, (C1-C6)alkoxy, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, —

    (CR7R8)v(C6-C12 aryl), —

    (CR7R8)v(4 to

         11)-membered heterocyclyl, —

    (C═

    O)—

    R9, —

    (C═

    O)—

    O—

    R9, —

    O—

    (C═

    O)—

    R9, —

    R9

    (C=O)—

    O—

    R10, —

    (CR9R10)q(C═

    O)(CR11R12)v(C6-C12)aryl, —

    (CR9R10)q(C═

    O)(CR11R12)v(4 to

         11)-membered heterocyclyl, —

    O—

    (C═

    O)—

    NR13R14, —

    NR13(C═

    O)—

    R14, —

    (C═

    O)—

    NR13R14, —

    R13

    (C═

    O)—

    NR14R15, —

    NR13R14, —

    NR13OR14, —

    S(O)kNR13R14, —

    S(O)j(C1-C6)alkyl, —

    O—

    SO2

    R15, —

    NR15

    S(O)k

    R16, —

    (CR17R18)qS(O)j(CR19R20)v(C6-C12)aryl, —

    (CR17R18)qS(O)j(CR19R20)v(4 to

         11)-membered heterocyclyl, —

    (CR17R18)vO(CR19R20)q(C6-C12)aryl, and —

    (CR17R18)vO(CR19R20)q(4 to

         11)-membered heterocyclyl, -k is selected from 1 and 2;

    j is selected from the group consisting of 0, 1, and 2;

    t, u, p, q, and v are each independently selected from the group consisting of 0, 1, 2, 3, 4, and 5;

    any 1 or 2 carbon atoms of any foregoing (4 to

         11)-membered heterocyclyl groups may be optionally substituted with an oxo (═

    O);

    any (C1-C6)alkyl, any (C6-C12)aryl, and any (4 to

         11)-membered heterocyclyl of the foregoing R6 groups may be optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, cyano, nitro, —

    CF3, —

    CFH2, —

    CF2H, trifluoromethoxy, azido, —

    OR21, —

    (C═

    O)—

    R21, —

    (C═

    O)—

    O—

    R21, —

    O—

    (C═

    O)—

    R21, —

    NR21(C═

    O)—

    R22, —

    (C═

    O)—

    NR21R22, —

    NR21R22, —

    NR21OR22, (C1-C6)alkyl, (C2-C8)alkenyl, (C2-C6)alkynyl, —

    (CR21R22)u(C6-C12)aryl, and —

    (CR21R22)u(4 to

         11)-membered heterocyclyl;

    each R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, and R22 group is independently selected from the group consisting of H, (C1-C6)alkyl, —

    (C═

    O)N(C1-C6)alkyl, —

    (CR23R24)p(C6-C12)aryl, and —

    (CR23R24)p(4 to

         11)-membered heterocyclyl;

    any 1 or 2 carbon atoms of the (4 to

         11)-membered heterocyclyl of each said R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, and R22 group may be optionally substituted with an oxo (═

    O);

    each R23 and R24 is independently selected from H and (C1-C6)alkyl;

    and wherein any of the above-mentioned substituents comprising a —

    CH3 (methyl), —

    CH2 (methylene), or —

    CH (methine) group which is not attached to a halo, —

    SO or —

    SO2 group or to a N, O or S atom optionally bears on said group a substituent independently selected from the group consisting of hydroxy, halo, (C1-C6)alkyl, (C1-C6)alkoxy, —

    NH2, —

    NH(C1-C6)(alkyl) and —

    N((C1-C6)(alkyl))2;

    with the proviso that —

    NR2R3 is not an unsubstituted group selected from embedded imageand the further proviso that when —

    R1 is embedded imagethen —

    NR2R3 is not an unsubstituted or substituted, fused or unfused group selected from embedded imageor a pharmaceutically acceptable salt or solvate thereof.

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