Water-soluble compound
First Claim
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1. A composition of matter comprised of a substrate comprised of a taxane, a magnetic moiety, and means for covalently binding said magnetic moiety to said taxane, thus producing a magnetic taxane.
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Abstract
A water-soluble magnetic anti-mitotic compound with a water-solubility of at least 100 micrograms per milliliter, a molecular weight of at least 150 grams per mole, a mitotic index factor of at least 10 percent, a positive magnetic susceptibility of at least 1,000×10−6 cgs, and a magnetic moment of at least 0.5 bohr magnetrons, wherein said compound is comprised of at least 7 carbon atoms and at least one inorganic atom with a positive magnetic susceptibility of at least 200×10−6 cgs.
28 Citations
29 Claims
- 1. A composition of matter comprised of a substrate comprised of a taxane, a magnetic moiety, and means for covalently binding said magnetic moiety to said taxane, thus producing a magnetic taxane.
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19. A composition of matter comprised of a substrate comprised of a taxane, a magnetic moiety, and means for covalently binding said magnetic moiety to said taxane, thus producing a magnetic taxane wherein
a. said magnetic moiety is comprised of a iron atom with a positive magnetic susceptibility of at least 2× - 10−
4 cgs,b. said substrate has appositive magnetic susceptibility of at least 1×
10−
3 cgs, andc. said magnetic moiety is further comprised of a ferrichrome. - View Dependent Claims (20, 21, 22)
- 10−
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23. A composition of matter comprised of a substrate comprised of a biologically active substrate and a magnetic moiety wherein:
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a. said biologically active substrate is operatively configured to bind to a binding domain of a tubulin, wherein said tubulin is part of a microtubule, b. said binding of said biologically active substrate to said binding domain alters the tread milling behavior of said microtubule such that said microtubule is stabilized, c. said magnetic moiety is covalently bound to said biologically active substrate. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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Specification