Analyte sensor
First Claim
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1. An analyte sensing device adapted for implantation into a host'"'"'s tissue, comprising:
- a sensor configured to measure an analyte in a host, wherein the sensor comprises a biointerface configured to promote at least one function selected from the group consisting of increasing fluid bulk surrounding at least a portion of the sensor in vivo, increasing bulk fluid flow surrounding at least a portion of the sensor in vivo, and increasing diffusion rates surrounding at least a portion of the sensor in vivo.
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Abstract
Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.
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Citations
74 Claims
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1. An analyte sensing device adapted for implantation into a host'"'"'s tissue, comprising:
a sensor configured to measure an analyte in a host, wherein the sensor comprises a biointerface configured to promote at least one function selected from the group consisting of increasing fluid bulk surrounding at least a portion of the sensor in vivo, increasing bulk fluid flow surrounding at least a portion of the sensor in vivo, and increasing diffusion rates surrounding at least a portion of the sensor in vivo. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 58)
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34. An analyte sensing device adapted for implantation into a host'"'"'s tissue, comprising:
a sensor for measuring an analyte in the host, wherein the sensor comprises a biointerface configured to irritate a surrounding in vivo environment. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. An analyte sensing device adapted for implantation into a host'"'"'s tissue, comprising:
a sensor for measuring an analyte in a host, wherein the sensor comprises a biointerface configured to suppress wound healing around at least a portion of the sensor in vivo. - View Dependent Claims (52, 53, 54, 55, 56, 57, 59, 60, 61, 62, 63, 64, 65, 66)
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67. A method for detecting an analyte in a host, comprising:
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providing an analyte sensing device adapted for transcutaneous insertion into the host, the device comprising a sensor for measuring the analyte in the host, wherein the sensor is configured to reduce noise in vivo;
inserting the sensor through the host'"'"'s skin and into the host;
waiting a first period of time, during which first period of time the sensor remains in the host, wherein the first period of time is sufficient for at least partial wound healing to occur;
initiating a sensor function; and
detecting a signal from the sensor, wherein the signal is indicative of a concentration of an analyte in the host. - View Dependent Claims (68, 69, 70, 71, 72, 73, 74)
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Specification