Cranial nerve stimulation to treat a vocal cord disorder

• US 20070027482A1
• Filed: 07/27/2005
• Published: 02/01/2007
• Est. Priority Date: 07/27/2005
• Status: Active Grant

• Current Assignee: LivaNova USA, Inc. (LivaNova Plc)
• Original Assignee: Cyberonics, Inc
• Inventors: Guzman, Albert, Maschino, Steven, Parnis, Steven
• Granted Patent: US 7,840,280 B2
• Time in Patent Office: Days
• US Class Current: 607/2
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence

Abstract

Disclosed is a method of treating a patient having a vocal cord disorder, comprising coupling at least one electrode to at least one cranial nerve of the patient, wherein the cranial nerve is selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve, and applying an electrical signal to the cranial nerve using the electrode to treat the vocal cord disorder. The electrode may be coupled to a branch of the vagus nerve selected from the group consisting of a recurrent laryngeal nerve, the external branch of a superior laryngeal nerve, the internal branch of a superior laryngeal nerve, and a pharyngeal plexus. Also disclosed is a computer readable program storage device encoded with instructions that, when executed by a computer, perform the method, and a medical device and a vocal cord disorder treatment system that may be used in performance of the method.

Claims

1. A method of treating a patient having a vocal cord disorder, comprising:

coupling at least one electrode to at least one cranial nerve of the patient selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve; and

applying an electrical signal to the at least one cranial nerve using the electrode to treat the vocal cord disorder.

2. The method of claim 1 wherein the vocal cord disorder comprises vocal cord paralysis.

3. The method of claim 1, wherein coupling at least one electrode to at least one cranial nerve comprises coupling the electrode to a branch of the vagus nerve of the patient selected from the group consisting of a recurrent laryngeal nerve, the external branch of a superior laryngeal nerve, the internal branch of a superior laryngeal nerve, and a pharyngeal plexus.

4. The method of claim 1, further comprising generating a physiological response to said electrical signal that is selected from the group consisting of an afferent action potential, an efferent action potential, an afferent hyperpolarization, and an efferent hyperpolarization.

5. The method of claim 4, wherein applying the electrical signal comprises generating an efferent action potential.

6. The method of claim 1, further comprising the steps of:

providing a programmable electrical signal generator;

coupling said signal generator said at least one electrode;

generating an electrical signal with the electrical signal generator;

and applying the electrical signal to the electrode.

7. The method of claim 6, further comprising programming the electrical signal generator to define the electrical signal by at least one parameter selected from the group consisting of a current magnitude, a pulse frequency, a pulse width, an on-time and an off-time, wherein said at least one parameter is selected to treat the vocal cord disorder.

8. The method of claim 1, further comprising detecting a symptom of the vocal cord disorder, and wherein applying the electrical signal is initiated in response to detecting said symptoms.

9. The method of claim 8, wherein the detecting the symptom comprises using a voice sensor.

10. The method of claim 1, wherein applying the electrical signal comprises applying said signal during a first treatment period, and said method further comprises applying a second electrical signal to the cranial nerve using the at least one electrode during a second treatment period to treat the vocal cord disorder.

11. The method of claim 10, further comprising detecting a symptom of the vocal cord disorder, wherein detecting the symptom comprises using a voice sensor;

and wherein the second treatment period is initiated in response to said step of detecting a symptom of the vocal cord disorder.

12. A method of treating a patient having a vocal cord disorder, comprising:

coupling at least one electrode to at least one cranial nerve of the patient selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve;

providing an electrical signal generator;

coupling said signal generator to said at least one electrode;

generating an electrical signal with the electrical signal generator; and

applying the electrical signal to the electrode to treat the vocal cord disorder.

13. The method of claim 12 further comprising:

detecting a symptom of the vocal cord disorder, wherein the step of applying the electrical signal to the electrode is initiated in response to detecting said symptom.

14. The method of claim 12 wherein coupling at least one electrode to at least one cranial nerve comprises coupling at least one electrode to a branch of the vagus nerve of the patient selected from the group consisting of a recurrent laryngeal nerve, the external branch of a superior laryngeal nerve, the internal branch of a superior laryngeal nerve, and a pharyngeal plexus.

15. A method of treating a patient having a vocal cord disorder, comprising:

coupling at least one electrode to at least one branch of a vagus nerve of the patient selected from the group consisting of a recurrent laryngeal nerve, the external branch of a superior laryngeal nerve, the internal branch of a superior laryngeal nerve, and a pharyngeal plexus; and

applying an electrical signal to said at least one branch of a vagus nerve using the electrode to treat the vocal cord disorder.

16. The method of claim 15 further comprising:

providing a programmable electrical signal generator;

coupling said signal generator to said at least one electrode;

generating an electrical signal with said electrical signal generator; and

wherein applying an electrical signal to said at least one branch of a vagus nerve comprises applying the electrical signal to said at least one electrode.

17. The method of claim 16, further comprising:

programming the electrical signal generator to define said electrical signal by a plurality of parameters selected from the group consisting of a current magnitude, a pulse width, a pulse frequency, an on-time and an off-time.

18. The method of claim 15, wherein applying an electrical signal to said at least one branch of a vagus nerve comprises applying said signal during a first treatment period, said method further comprising applying a second electrical signal to the at least one branch of a vagus nerve during a second treatment period.

19. The method of claim 18, wherein said first treatment period comprises a period ranging from one hour to six months, and wherein said second treatment period comprises a period ranging from one month to 10 years.

20. The method of claim 15, wherein the at least one electrode is selected from the group consisting of a spiral electrode and a paddle electrode.