Multiple Chamber Container

• US 20070029001A1
• Filed: 08/02/2006
• Published: 02/08/2007
• Est. Priority Date: 08/02/2005
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Desbrosses, Freddy, Bonnot, Denis, Trouilly, Jean Luc, Melin, Christian
• Granted Patent: US 8,485,727 B2
• Time in Patent Office: Days
• US Class Current: 141/114
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/17 Amino acids, peptides or proteins
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1462 Containers with provisions for hanging, e.g. integral adaptations of the container accessories for hanging the container A61M5/1414
• CPC Class Codes: A61J 1/2024 having peelable seals
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 36/63 Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: B32B 27/08 of synthetic resin
• CPC Class Codes: G01N 21/783 for analysing gases
• CPC Class Codes: G01N 31/225 for oxygen, e.g. including dissolved oxygen

Abstract

A multiple chamber container for separately storing components of a parenteral nutritional formulation is provided. The multiple chamber container may include frangible barriers, preferably peelable seals separating the chambers from each other. The container preferably facilitates the selective activation of the peelable seals to permit the admixing of less than all the separately stored components. The container may include a chamber positioned at each of the opposite lateral ends of the container and at least one additional chamber between the lateral chambers. The at least one additional chamber may have a longitudinal length substantially less than the longitudinal length of at least one of the lateral chambers. This configuration allows for selective opening of the seals since when rolling the container from the top avoids pressurizing the at least one additional chamber and inadvertent activation of a seal. The longitudinal length of the at least one additional chamber may be from about two-thirds to about three-fourths the longitudinal length of at least one of the lateral chambers. Alternatively, the container may include a hanger flap extending from a top end of the container towards the bottom end a substantially greater distance relative to the at least one additional chamber than the lateral chambers.

Claims

1. A flexible container for storing medical products comprising:

a) a plurality of adjacent chambers, a first chamber positioned at one lateral end of the container, a second chamber positioned at an opposite lateral end of the chamber and at least one additional chamber positioned between the first and second chambers;

b) a first frangible barrier separating the first chamber from the at least one additional chamber and a second frangible barrier separating the second chamber from the at least one additional chamber;

c) at least one port located at one end the container;

each port providing fluid communication with a different one of the first, second and at least one additional chambers; and

d) a longitudinal length of the at least one additional chamber being substantially less than at least one of a longitudinal length of the first and second chamber.

2. The flexible container of claim 1 wherein the longitudinal length of the at least one additional chamber is substantially less than the longitudinal length of both the first and second chambers.

3. The flexible container of claim 1 wherein the longitudinal length of one of the first and second chambers is substantially less than the longitudinal length of the at least one additional chamber.

4. The flexible container of claim 1 wherein the longitudinal length of one of the first and second chambers is equal to the longitudinal length of the at least one additional chamber.

5. The flexible container of claim 1 wherein the container is in the form of a bag and is comprised of a multilayer polymeric material.

6. The flexible container of claim 5 wherein the first and second frangible barriers are peelable seals.

7. The flexible container of claim 6 further including a hanger portion at an end opposite to the at least one port.

8. The flexible container of claim 7 further including three ports, each port providing fluid communication with a different one of the first, second, and at least one additional chambers.

9. The flexible container of claim 8 wherein the hanger portion defines an uppermost border of the first, second, and at least one additional chamber.

10. The flexible container of claim 9 further including a component of a parenteral formulation for fluid restricted patients in each of the first, second and at least one additional chambers wherein one of the components includes cysteine.

11. The flexible container of claim 10 wherein the hanger portion includes an opening for hanging the container on a stand or hook.

12. A multilayer flexible container for storing medical products comprising:

a) a first end and a second end;

b) a first chamber positioned at one side end of the container, a third chamber positioned at an opposite side end of the container, and a second chamber positioned between the first and third chambers;

c) a first frangible barrier between the first and second chambers and a second frangible barrier between the second and third chambers;

d) a first port positioned at the second end of the container and providing fluid communication with one of the first and second chamber; and

a second port positioned at the second end of the container and providing fluid communication with the third chamber; and

e) a hanger portion extending from the first end of the container, the hanger portion defining a border of each of the first, second and third chambers, the hanger portion extending towards the second end a substantially greater distance with respect to at least the second chamber than any of the other of the at least second chamber.

13. The multilayer flexible container of claim 12 wherein the hanger portion extends towards the second end a substantially greater distance with respect to the second chamber and one of the first and third chamber than the other of the first and third chamber.

14. The multilayer flexible container of claim 12 wherein rolling the multilayer flexible container starting at the first end activates one of the first and second peelable seals before activating the other of the first and second peelable seals.

15. The multilayer flexible container of claim 14 wherein the first and second frangible barriers are peelable seals.

16. The multilayer flexible container of claim 15 further including a third port providing fluid communication with the other of the first and second chambers.

17. The multilayer flexible container of claim 16 wherein the hanger portion includes an opening for hanging the container on a stand or hook.

18. A flexible multilayer bag for storing and admixing medical products comprising;

a) top, bottom, first and second lateral sides;

b) a first chamber, a second chamber, and a third chamber;

c) a first frangible barrier separating the first and second chambers and a second frangible barrier separating the second and third chambers; and

d) at least two ports located at the bottom side, each port providing access to a different one of the first, second, and third chambers

wherein the first, second and third chambers are arranged such that rolling the bag from the top side activates one of the first and second frangible barriers before activating the other of the first and second frangible barriers.

19. The flexible multilayer bag of claim 18 wherein the first and second frangible barriers are peelable seals.

20. A flexible multilayer bag for storing and admixing medical products comprising:

a) top, bottom, left, and right sides;

b) a first chamber, a second chamber, and a third chamber;

c) a plurality of frangible barriers separating the first, second and third chambers from each other; and

d) at least two ports located at the bottom side, each port providing access to a different one of the first, second, and third chambers

wherein the first, second and third chambers are arranged such that rolling the bag starting at an intersection between the top side and one of the left and right sides allows sequential activation of the frangible barriers.