Opthalmic sensor
First Claim
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1. An ophthalmic sensor, comprising:
- an ophthalmic device having a polymer matrix; and
a molecular sensing moiety in and/or on said ophthalmic device, wherein the molecular sensing moiety is capable of interacting or reacting with sugar to provide an optical signal which is indicative of sugar level in an ocular fluid and is covalently attached to the polymer matrix by copolymerizing a lens-forming material including a compound having the structural formula (1) or (2);
wherein R′
is H or a C3-C25 radical having an olefinically unsaturated group;
R is H, NR1R2, CN, OCH3, or a radical constituent capable of donating an electron to or accenting an electron from adjacent aromatic system, wherein R1 is H or C1-C6 alkyl while R2 is C1-C6 alkyl or a C3-C25 radical terminated with an olefinically unsaturated group, provided that at least one of R′ and
R has an olefinically unsaturated group; and
n is an integer from 1 to 5.
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Abstract
This invention is generally related to a biocompatible sensor for detecting/measuring sugar, especially glucose, in an ocular fluid in a non-invasive or minimally invasive manner and a method for using the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of an ophthalmic device comprising a molecular sensing moiety which interacts or, reacts with sugar to provide an optical signal which is indicative of sugar level in an ocular fluid.
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Citations
16 Claims
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1. An ophthalmic sensor, comprising:
- an ophthalmic device having a polymer matrix; and
a molecular sensing moiety in and/or on said ophthalmic device, wherein the molecular sensing moiety is capable of interacting or reacting with sugar to provide an optical signal which is indicative of sugar level in an ocular fluid and is covalently attached to the polymer matrix by copolymerizing a lens-forming material including a compound having the structural formula (1) or (2);
wherein R′
is H or a C3-C25 radical having an olefinically unsaturated group;
R is H, NR1R2, CN, OCH3, or a radical constituent capable of donating an electron to or accenting an electron from adjacent aromatic system, wherein R1 is H or C1-C6 alkyl while R2 is C1-C6 alkyl or a C3-C25 radical terminated with an olefinically unsaturated group, provided that at least one of R′ and
R has an olefinically unsaturated group; and
n is an integer from 1 to 5. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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15. The ophthalmic sensor of claim 1, wherein the lens-forming material comprises a water-soluble and/or meltable at room temperature prepolymer.
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16. The ophthalmic sensor of claim 15, wherein the prepolymer is a water-soluble crosslinkable poly(vinyl alcohol) prepolymer;
- a water-soluble vinyl group-terminated polyurethane which is obtained by reacting an isocyanate-capped polyurethane with an ethylenically unsaturated amine (primary or secondary amine) or an ethylenically unsaturated monohydroxy compound, wherein the isocyanate-capped polyurethane can be a copolymerization product of at least one polyalkylene glycol, a compound containing at least 2 hydroxyl groups, and at least one compound with two or more isocyanate groups;
derivatives of a polyvinyl alcohol, polyethyleneimine or polyvinylamine;
a water-soluble crosslinkable polyurea prepolymer;
a crosslinkable polyacrylamide;
a crosslinkable statistical copolymer of vinyl lactam, MMA and a comonomer;
a crosslinkable copolymer of vinyl lactam, vinyl acetate and vinyl alcohol;
a polyether-polyester copolymer with crosslinkable side chains;
a branched polyalkylene glycol-urethane prepolymer;
a polyalkylene glycol-tetra(meth)acrylate prepolymer;
or a crosslinkable polyallylamine gluconolactone prepolymer.
- a water-soluble vinyl group-terminated polyurethane which is obtained by reacting an isocyanate-capped polyurethane with an ethylenically unsaturated amine (primary or secondary amine) or an ethylenically unsaturated monohydroxy compound, wherein the isocyanate-capped polyurethane can be a copolymerization product of at least one polyalkylene glycol, a compound containing at least 2 hydroxyl groups, and at least one compound with two or more isocyanate groups;
- an ophthalmic device having a polymer matrix; and
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2-9. -9. (canceled)
Specification