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Method for Preparing Branched Functionalized Polymers Using Branched Polyol Cores

  • US 20070031371A1
  • Filed: 07/18/2006
  • Published: 02/08/2007
  • Est. Priority Date: 07/18/2005
  • Status: Active Grant
First Claim
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1. A method of preparing a multiarm polymer, comprising:

  • (a) optionally, to a branched polyol bearing at least three hydroxyl groups or a mixture of branched polyols comprising a branched polyol bearing at least three hydroxyl groups, attaching a water-soluble and non-peptidic polymer segment to the branched polyol at the site of at least one of the hydroxyl groups;

    (b) reacting the branched polyol, in one or more reaction steps, with one or more functionalizing reagents to effect substitution of an ionizable functional group or a protected ionizable functional group, —

    Y, to form a mixture comprising (i) unsubstituted branched polyol containing no —

    Y groups;

    (ii) a monosubstituted polyol comprising a single —

    Y group, and (iii) a multisubstituted polyol comprising at least two —

    Y groups;

    (c) where —

    Y is a protected ionizable functional group, deprotecting the ionizable functional group;

    (d) purifying the mixture to separate the monosubstituted polyol from the unsubstituted and multisubstituted polyol species; and

    (e) if optional step (a) is absent, attaching a water-soluble and non-peptidic polymer segment to the monosubstituted branched polyol at the site of at least one of the hydroxyl groups either before or after said purifying step (d).

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