Modalities for the treatment of degenerative diseases of the retina
First Claim
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1. A method of treating or preventing retinal degeneration, comprising use of a cell selected from the group consisting of at least one of:
- RPE cells, RPE-like cells, RPE or RPE-like progenitors derived from mammalian embryonic stem cells.
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Abstract
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
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Citations
18 Claims
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1. A method of treating or preventing retinal degeneration, comprising use of a cell selected from the group consisting of at least one of:
- RPE cells, RPE-like cells, RPE or RPE-like progenitors derived from mammalian embryonic stem cells.
- View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for the spontaneous differentiation of hES cells into cells RPE, RPE-like, or RPE progenitor cells, said method comprising:
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a) allowing hES cell cultures to overgrow on MEF;
b) allowing the hES cell cultures to form a thick multilayer of cells;
c) culturing the hES cells;
d) isolation and culture of the pigmented RPE, RPE-like, and/or RPE progenitor cells from the resultant cell cultures. - View Dependent Claims (9, 10, 11, 12, 13, 16, 17)
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14. A method for the derivation of RPE lines or precursors to RPE cells that have an increased ability to prevent neovascularization, said method comprising:
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a) aging a somatic cell from an animal such that telomerase is shortened wherein at least 10% of the normal replicative lifespan of the cell has been passed; and
,b) using the somatic cell as a nuclear transfer donor cell to create cells that overexpress angiogenesis inhibitors, wherein the angiogenesis inhibitors can be Pigment Epithelium Derived Factor (PEDF/EPC-1). - View Dependent Claims (15)
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18. A method for the treatment of Parkinson'"'"'s disease comprising the transplantation of RPE-like cells or progenitor cells.
Specification