Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties

• US 20070031496A1
• Filed: 08/04/2006
• Published: 02/08/2007
• Est. Priority Date: 08/04/2005
• Status: Abandoned Application

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Li, Shu, Bhatti, Gurdish, Wong, Patrick, Edgren, David
• Application Number:
  US11/499,008
• Publication Number:
  US 20070031496A1
• Time in Patent Office: Days
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61P 25/24 Antidepressants

Abstract

Disclosed are osmotic dosage forms including an osmotic core; a semi-permeable membrane that surrounds the osmotic core and comprises a blend of a cellulose acetate polymer and an acrylate copolymer; and an exit formed through the semi-permeable membrane. Also disclosed are methods of making and administering such dosage forms.

Claims

1. An osmotic dosage form comprising:

an osmotic core;

a semi-permeable membrane that surrounds the osmotic core and comprises a blend of a cellulose acetate polymer and an acrylate copolymer; and

an exit formed through the semi-permeable membrane.

2. The osmotic dosage form of claim 1, wherein the blend comprises the cellulose acetate polymer in an amount equal to or greater than about 50 wt % based on a total dry weight of the blend.

3. The osmotic dosage form of claim 2, wherein the blend comprises the cellulose acetate polymer in an amount equal to or greater than about 60 wt % based on a total dry weight of the blend.

4. The osmotic dosage form of claim 3, wherein the blend comprises the cellulose acetate polymer in an amount equal to or greater than about 70 wt %, based on a total dry weight of the blend.

5. The osmotic dosage form of claim 1, wherein the blend comprises acrylate copolymer in an amount ranging from about 0.01 wt % to about 50 wt %, based on a total dry weight of the blend.

6. The osmotic dosage form of claim 5, wherein the blend comprises acrylate copolymer in an amount ranging from about 10 wt % to about about 30 wt %, based on a total dry weight of the blend.

7. The osmotic dosage form of claim 6, wherein the blend comprises acrylate copolymer in an amount ranging from about 15 wt % to about 25 wt %, based on a total dry weight of the blend.

8. The osmotic dosage form of claim 1, wherein the blend further comprises a flux enhancer.

9. The osmotic dosage form of claim 8, wherein the amount of flux enhancer ranges from about 0.01 wt % to about 25 wt %, based on a total dry weight of the blend.

10. The osmotic dosage form of claim 9, wherein the amount of flux enhancer ranges from about 5 wt % to about 20 wt %, based on a total dry weight of the blend.

11. The osmotic dosage form of claim 10, wherein the amount of flux enhancer ranges from about 10 wt % to about 15 wt %, based on a total dry weight of the blend.

12. A method comprising:

administering the osmotic dosage form of claim 1 to a patient.

13. A method comprising:

providing an osmotic core;

coating the osmotic core with a semi-permeable membrane that comprises a blend of a cellulose acetate polymer and an acrylate copolymer;

forming an exit through the semi-permeable membrane; and

administering the coated osmotic core to a patient.

14. The method of claim 13, wherein the blend comprises the cellulose acetate polymer in an amount equal to or greater than about 50 wt % based on a total dry weight of the blend.

15. The method of claim 14, wherein the blend comprises the cellulose acetate polymer in an amount equal to or greater than about 60 wt % based on a total dry weight of the blend.

16. The method of claim 15, wherein the blend comprises the cellulose acetate polymer in an amount equal to or greater than about 70 wt %, based on a total dry weight of the blend.

17. The method of claim 13, wherein the blend comprises acrylate copolymer in an amount ranging from about 0.01 wt % to about 50 wt %, based on a total dry weight of the blend

18. The method of claim 17, wherein the blend comprises acrylate copolymer in an amount ranging from about 10 wt % to about about 30 wt %, based on a total dry weight of the blend

19. The method of claim 18, wherein the blend comprises acrylate copolymer in an amount ranging from about 15 wt % to about 25 wt %, based on a total dry weight of the blend.

20. The method of claim 13, wherein the blend further comprises a flux enhancer.

21. The method of claim 20, wherein the amount of flux enhancer ranges from about 0.01 wt % to about 25 wt %, based on a total dry weight of the blend.

22. The method of claim 21, wherein the amount of flux enhancer ranges from about 5 wt % to about 20 wt %, based on a total dry weight of the blend.

23. The method of claim 22, wherein the amount of flux enhancer ranges from about 10 wt % to about 15 wt %, based on a total dry weight of the blend.