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GEL COMPOSITION FOR CELLULAR ADHESION INHIBITION

  • US 20070031498A1
  • Filed: 08/02/2006
  • Published: 02/08/2007
  • Est. Priority Date: 08/02/2005
  • Status: Abandoned Application
First Claim
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1. A composition for inhibiting cellular adhesion comprising:

  • 0.1 to 8 weight percent of a cellular adhesion inhibitory agent based upon the total weight of the composition, the inhibitory agent being selected from the group consisting of alginate, chondroitan sulfate, dermatan sulfate, dextran sulfate, hyaluronic acid, heparin, heparin sulfate, keratan sulfate, and pentosan polysulfate; and

    92 to 99.9 weight percent of a crosslinked hydrogel matrix based upon the total weight of the composition, the crosslinked hydrogel matrix comprising;

    a first hydrogel component comprising a polyethylene glycol polymer having at least one electrophilic group; and

    at least one additional hydrogel component having at least one nucleophilic group, the at least one additional hydrogel component being selected from the group consisting of polyethylene glycol polymers, polypeptides, and polysaccharides.

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