Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
First Claim
1. An electrochemical deblocking solution for use on an electrode microarray comprising an acid-source reducible solvent, an organic salt, and an organic base.
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Abstract
There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.
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Citations
31 Claims
- 1. An electrochemical deblocking solution for use on an electrode microarray comprising an acid-source reducible solvent, an organic salt, and an organic base.
- 15. A method of electrochemical deblocking of an acid-labile protecting group, comprising applying a voltage or a current to at least one electrode of an array of electrodes, wherein, the array of electrodes is covered by an electrochemical deblocking solution, wherein the electrochemical deblocking solution comprises an acid-source reducible solvent, an organic salt, and an organic base.
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30. An electrochemical deblocking solution comprising approximately 0.01 to 200 mM of lutidine, approximately 0.1 to 100 mM benzoquinone, approximately 0.1 to 2 M hydroquinone, approximately 0.1 to 5 M tetraethylammonium p-toluenesulfonate, and a solvent having approximately 10% to, 99% acetonitrile and approximately 1% to 90% methanol.
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31. An electrochemical deblocking solution comprising approximately 0.01 to 200 mM of N,N-diisopropylethylamine, approximately 0.1 to 100 mM 2,5-di-tert-butyl benzoquinone, approximately 0.1 to 100 mM 2,5-di-tert-butyl hydroquinone, approximately 0.1 to 5 M tetrabutylammonium hexafluorophosphate, and a solvent having approximately 1% to 99% dichloromethane and approximately 1% to 99% isopropanol.
Specification